Triggering P53 After Cytokinesis Failure

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2004 Jun 9

PMID 15184396

Citations 29

Authors

P Todd Stukenberg

Affiliations

Soon will be listed here.

Abstract

Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cytokinesis, making this phenomenon even more puzzling.

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