Role of Prolonged Mitotic Checkpoint Activation in the Formation and Treatment of Cancer
Overview
Authors
Affiliations
Mitotic abnormalities are a common feature of human cancer cells, and recent studies have provided evidence that such abnormalities may play a causative, rather than merely incidental role, in tumorigenesis. One such abnormality is prolonged activation of the mitotic checkpoint, which can be provoked by a number of the gene changes that drive tumor formation. At the same time, antimitotic chemotherapeutics exert their clinical efficacy through the large-scale induction of prolonged mitotic checkpoint activation, indicating that mitotic arrest is influential in both the formation and treatment of human cancer. However, how this influence occurs is not well understood. In this perspective, we will discuss the current evidence in support of the potential mechanisms by which prolonged activation of the mitotic checkpoint affects both tumorigenesis and antimitotic chemotherapy.
Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition.
Rahman M, Olson I, Mansour M, Carlstrom L, Sutiwisesak R, Saber R Mol Cancer Res. 2022; 20(6):938-948.
PMID: 35191501 PMC: 9196639. DOI: 10.1158/1541-7786.MCR-21-0029.
Odborn Jonsson L, Sahi M, Lopez-Lorenzo X, Keller F, Kostopoulou O, Herold N Int J Mol Sci. 2021; 22(7).
PMID: 33915913 PMC: 8036447. DOI: 10.3390/ijms22073664.
The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?.
Luserna di Rora A, Martinelli G, Simonetti G J Hematol Oncol. 2019; 12(1):123.
PMID: 31771633 PMC: 6880427. DOI: 10.1186/s13045-019-0808-4.
Cao D, Zhao J, Nguyan L, Nguyen L, Khanal S, Dang X Front Immunol. 2019; 10:1152.
PMID: 31191531 PMC: 6540964. DOI: 10.3389/fimmu.2019.01152.
The origins and functions of hepatic polyploidy.
Zhang S, Lin Y, Tarlow B, Zhu H Cell Cycle. 2019; 18(12):1302-1315.
PMID: 31096847 PMC: 6592246. DOI: 10.1080/15384101.2019.1618123.