NAADP-induced Ca2+ Release -- a New Signalling Pathway

Overview

Journal Biol Cell

Specialty Cell Biology

Date 2004 Apr 20

PMID 15093124

Citations 17

Authors

Sandip Patel

Affiliations

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Abstract

Changes in cystosolic Ca2+ concentration are critical for the regulation of numerous cellular events. Mobilisation of intracellular Ca2+ stores by Ca2+ mobilising messengers is a highly conserved mechanism whereby different agonists mediate their cellular effects. NAADP is the newest of these messengers to be described. Accumulating evidence suggests that NAADP targets a novel intracellular Ca2+ release channel that under certain conditions can inactivate prior to opening. These channels are likely located on Ca2+ stores distinct from the endoplasmic reticulum, the activation of which evokes complex changes in Ca2+ involving cross-talk with other intracellular Ca2+ channels. Recent demonstrations of changes in cellular NAADP levels by physiologically relevant stimuli establish the importance of this molecule in the control of calcium dynamics.

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