The Endo-lysosomal System As an NAADP-sensitive Acidic Ca(2+) Store: Role for the Two-pore Channels

Overview

Journal Cell Calcium

Publisher Elsevier

Specialties Cell Biology
Endocrinology

Date 2011 May 3

PMID 21529939

Citations 29

Authors

Sandip Patel

Latha Ramakrishnan

Taufiq Rahman

Amro Hamdoun

Jonathan S Marchant

Colin W Taylor

Eugen Brailoiu

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

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