Meiotic Recombination Hot Spots and Human DNA Diversity

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2004 Apr 7

PMID 15065666

Citations 43

Authors

Alec J Jeffreys

J Kim Holloway

Liisa Kauppi

Celia A May

Rita Neumann

M Timothy Slingsby

Adam J Webb

Affiliations

Soon will be listed here.

Abstract

Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine-scale distribution and processes of recombination in human chromosomes, or how these impact on patterns of human diversity. We have therefore developed sperm typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that human crossovers are far from randomly distributed but instead are targeted into very narrow hot spots that can profoundly influence patterns of haplotype diversity in the human genome. These hot spots provide fundamental information on processes of human crossover and gene conversion, as well as evidence that they can violate basic rules of Mendelian inheritance.

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