A Gradient of Sex Linkage in the Pseudoautosomal Region of the Human Sex Chromosomes

Overview

Journal Nature

Specialty Science

Date 1986 Jan 23

PMID 3941746

Citations 110

Authors

F Rouyer

M C Simmler

C Johnsson

G Vergnaud

H J Cooke

J Weissenbach

Affiliations

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Abstract

Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.

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