Alec J Jeffreys
Overview
Explore the profile of Alec J Jeffreys including associated specialties, affiliations and a list of published articles.
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39
Citations
1511
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Recent Articles
1.
Weiss M, Wilson V, Chan C, Turner T, Jeffreys A
Am J Primatol
. 2020 Jan;
16(1):73-79.
PMID: 31968875
Analysis of tandem-repetitive minisatellite DNA in humans provides great discriminatory power in paternity identification and individualization of tissue samples. The molecular probes used to study these hyper-variable loci are here...
2.
Odenthal-Hesse L, Berg I, Veselis A, Jeffreys A, May C
PLoS Genet
. 2014 Feb;
10(2):e1004106.
PMID: 24516398
Meiotic recombination ensures the correct segregation of homologous chromosomes during gamete formation and contributes to DNA diversity through both large-scale reciprocal crossovers and very localised gene conversion events, also known...
3.
Jeffreys A
Investig Genet
. 2013 Nov;
4(1):21.
PMID: 24245655
In this interview we talk with Professor Sir Alec Jeffreys about DNA fingerprinting, his wider scientific career, and the past, present and future of forensic DNA applications.The podcast with excerpts...
4.
Huang Y, Hidalgo-Bravo A, Zhang E, Cotton V, Mendez-Bermudez A, Wig G, et al.
Nucleic Acids Res
. 2013 Sep;
42(1):315-27.
PMID: 24057213
Linear chromosomes are stabilized by telomeres, but the presence of short dysfunctional telomeres triggers cellular senescence in human somatic tissues, thus contributing to ageing. Approximately 1% of the population inherits...
5.
Jeffreys A, Cotton V, Neumann R, Lam K
Proc Natl Acad Sci U S A
. 2012 Dec;
110(2):600-5.
PMID: 23267059
PRDM9 plays a key role in specifying meiotic recombination hotspot locations in humans and mice via recognition of hotspot sequence motifs by a variable tandem-repeat zinc finger domain in the...
6.
Sarbajna S, Denniff M, Jeffreys A, Neumann R, Artigas M, Veselis A, et al.
Hum Mol Genet
. 2012 Feb;
21(9):2029-38.
PMID: 22291443
Recombination plays a fundamental role in meiosis. Non-exchange gene conversion (non-crossover, NCO) may facilitate homologue pairing, while reciprocal crossover (CO) physically connects homologues so they orientate appropriately on the meiotic...
7.
Berg I, Neumann R, Sarbajna S, Odenthal-Hesse L, Butler N, Jeffreys A
Proc Natl Acad Sci U S A
. 2011 Jul;
108(30):12378-83.
PMID: 21750151
PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of...
8.
Freeman P, Macfarlane C, Collier P, Jeffreys A, Badge R
Hum Mutat
. 2011 May;
32(8):978-88.
PMID: 21560187
Long interspersed nuclear element 1 (L1) retrotransposons are the only autonomously mobile human transposable elements. L1 retrotransposition has shaped our genome via insertional mutagenesis, sequence transduction, pseudogene formation, and ectopic...
9.
Berg I, Neumann R, Lam K, Sarbajna S, Odenthal-Hesse L, May C, et al.
Nat Genet
. 2010 Sep;
42(10):859-63.
PMID: 20818382
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in humans and mice. PRDM9 contains a zinc finger array that, in humans, can recognize...
10.
Neumann R, Lawson V, Jeffreys A
Proc Natl Acad Sci U S A
. 2010 Apr;
107(18):8304-9.
PMID: 20404158
Copy number variation in the human genome is prevalent but relatively little is known about the dynamics of DNA rearrangement. We therefore used the duplicated gamma-globin genes as a simple...