Membranes As Messengers in T Cell Adhesion Signaling

Overview

Journal Nat Immunol

Date 2004 Mar 31

PMID 15052266

Citations 89

Authors

Michael L Dustin

Trever G Bivona

Mark R Philips

Affiliations

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Abstract

Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery of signals may be crucial, and membrane trafficking from endosomes and the Golgi apparatus seem to be essential in delivering the messages from spatially segregated surface receptors.

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