T-cell Immune Adaptor SKAP1 Regulates the Induction of Collagen-induced Arthritis in Mice

Overview

Journal Immunol Lett

Specialty Allergy & Immunology

Date 2016 May 17

PMID 27181093

Citations 12

Authors

Xin Smith

Alison Taylor

Christopher E Rudd

Affiliations

Soon will be listed here.

Abstract

SKAP1 is an immune cell adaptor that couples the T-cell receptor with the 'inside-out' signalling pathway for LFA-1 mediated adhesion in T-cells. A connection of SKAP1 to the regulation of an autoimmune disorder has not previously been reported. In this study, we show that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis (CIA), both in terms of incidence or severity. Skap1-/- T-cells were characterised by a selective reduction in the presence IL-17+ (Th17) in response to CII peptide and a marked reduction of joint infiltrating T-cells in Skap1-/- mice. SKAP1 therefore represents a novel connection to Th17 producing T-cells and is new potential target in the therapeutic intervention in autoimmune and inflammatory diseases.

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