Class 1 Integrons Increase Trimethoprim-sulfamethoxazole MICs Against Epidemiologically Unrelated Stenotrophomonas Maltophilia Isolates

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2004 Jan 27

PMID 14742234

Citations 37

Authors

Raquel Barbolla

Mariana Catalano

Betina E Orman

Angela Famiglietti

Carlos Vay

Jorgelina Smayevsky

Daniela Centron

Silvia A Pineiro

Affiliations

Soon will be listed here.

Abstract

Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31 Stenotrophomonas maltophilia isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the sul1 determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections.

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References

Laing F, Ramotar K, Read R, Alfieri N, Kureishi A, Henderson E . Molecular epidemiology of Xanthomonas maltophilia colonization and infection in the hospital environment. J Clin Microbiol. 1995; 33(3):513-8. PMC: 227982. DOI: 10.1128/jcm.33.3.513-518.1995. View

Struelens M . Consensus guidelines for appropriate use and evaluation of microbial epidemiologic typing systems. Clin Microbiol Infect. 1996; 2(1):2-11. DOI: 10.1111/j.1469-0691.1996.tb00193.x. View

Centron D, Roy P . Presence of a group II intron in a multiresistant Serratia marcescens strain that harbors three integrons and a novel gene fusion. Antimicrob Agents Chemother. 2002; 46(5):1402-9. PMC: 127176. DOI: 10.1128/AAC.46.5.1402-1409.2002. View

Orman B, Pineiro S, Arduino S, Galas M, Melano R, Caffer M . Evolution of multiresistance in nontyphoid salmonella serovars from 1984 to 1998 in Argentina. Antimicrob Agents Chemother. 2002; 46(12):3963-70. PMC: 132759. DOI: 10.1128/AAC.46.12.3963-3970.2002. View

Whitby P, Carter K, Burns J, Royall J, LiPuma J, Stull T . Identification and detection of Stenotrophomonas maltophilia by rRNA-directed PCR. J Clin Microbiol. 2000; 38(12):4305-9. PMC: 87596. DOI: 10.1128/JCM.38.12.4305-4309.2000. View

Huovinen P, Sundstrom L, Swedberg G, SKOLD O . Trimethoprim and sulfonamide resistance. Antimicrob Agents Chemother. 1995; 39(2):279-89. PMC: 162528. DOI: 10.1128/AAC.39.2.279. View

Muder R, Harris A, Muller S, Edmond M, Chow J, Papadakis K . Bacteremia due to Stenotrophomonas (Xanthomonas) maltophilia: a prospective, multicenter study of 91 episodes. Clin Infect Dis. 1996; 22(3):508-12. DOI: 10.1093/clinids/22.3.508. View

Quelle L, Catalano M . Efficacy of two DNA fingerprinting methods for typing Acinetobacter baumannii isolates. Diagn Microbiol Infect Dis. 2001; 39(4):215-23. DOI: 10.1016/s0732-8893(01)00238-3. View

Bushby S . Trimethoprim-sulfamethoxazole: in vitro microbiological aspects. J Infect Dis. 1973; 128:Suppl:442-62 p. DOI: 10.1093/infdis/128.supplement_3.s442. View

10.

Avison M, Higgins C, von Heldreich C, Bennett P, Walsh T . Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophilia. Antimicrob Agents Chemother. 2001; 45(2):413-9. PMC: 90306. DOI: 10.1128/AAC.45.2.413-419.2001. View

11.

Tolmasky M, Crosa J . Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331. Plasmid. 1993; 29(1):31-40. DOI: 10.1006/plas.1993.1004. View

12.

Alonso A, Martinez J . Multiple antibiotic resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother. 1997; 41(5):1140-2. PMC: 163865. DOI: 10.1128/AAC.41.5.1140. View

13.

Levesque C, Piche L, Larose C, Roy P . PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob Agents Chemother. 1995; 39(1):185-91. PMC: 162507. DOI: 10.1128/AAC.39.1.185. View

14.

Valdezate S, Vindel A, Loza E, Baquero F, Canton R . Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains. Antimicrob Agents Chemother. 2001; 45(5):1581-4. PMC: 90512. DOI: 10.1128/AAC.45.5.1581-1584.2001. View

15.

Alonso A, Sanchez P, Martinez J . Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance. Antimicrob Agents Chemother. 2000; 44(7):1778-82. PMC: 89961. DOI: 10.1128/AAC.44.7.1778-1782.2000. View

16.

Denton M, Kerr K . Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin Microbiol Rev. 1998; 11(1):57-80. PMC: 121376. DOI: 10.1128/CMR.11.1.57. View

17.

Berg G, Roskot N, Smalla K . Genotypic and phenotypic relationships between clinical and environmental isolates of Stenotrophomonas maltophilia. J Clin Microbiol. 1999; 37(11):3594-600. PMC: 85701. DOI: 10.1128/JCM.37.11.3594-3600.1999. View