Safety and Efficacy of Antimicrobial Peptides Against Naturally Acquired Leishmaniasis

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2004 Jan 27

PMID 14742227

Citations 19

Authors

J Alberola

A Rodriguez

O Francino

X Roura

L Rivas

D Andreu

Affiliations

Soon will be listed here.

Abstract

Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.

Citing Articles

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease.

Robledo S, Perez-Silanes S, Fernandez-Rubio C, Poveda A, Monzote L, Gonzalez V Pathogens. 2023; 12(7).

PMID: 37513786 PMC: 10383258. DOI: 10.3390/pathogens12070939.

Peptides to Tackle Leishmaniasis: Current Status and Future Directions.

Robles-Loaiza A, Pinos-Tamayo E, Mendes B, Teixeira C, Alves C, Gomes P Int J Mol Sci. 2021; 22(9).

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Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites.

Sabia Junior E, Menezes L, Araujo I, Schwartz E Toxins (Basel). 2019; 11(10).

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Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review.

de Annunzio S, Costa N, Mezzina R, Graminha M, Fontana C Int J Mol Sci. 2019; 20(16).

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Control of Citrus Post-harvest Green Molds, Blue Molds, and Sour Rot by the Cecropin A-Melittin Hybrid Peptide BP21.

Wang W, Liu S, Deng L, Ming J, Yao S, Zeng K Front Microbiol. 2018; 9:2455.

PMID: 30364142 PMC: 6191494. DOI: 10.3389/fmicb.2018.02455.

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