Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Aug 11

PMID 31398812

Citations 19

Authors

Sarah Raquel de Annunzio

Natalia Caroline Silva Costa

Rafaela Dalbello Mezzina

Marcia A S Graminha

Carla Raquel Fontana

Affiliations

Soon will be listed here.

Abstract

Recent scientific research has shown the use of chlorin, phthalocyanines, and porphyrins derivatives as photosensitizers in photodynamic therapy in the treatment of various pathologies, including some of the major skin diseases. Thus, the main goal of this critical review is to catalog the papers that used these photosensitizers in the treatment of acne vulgaris, psoriasis, papillomavirus infections, cutaneous leishmaniasis, and skin rejuvenation, and to explore the photodynamic therapy mechanisms against these conditions alongside their clinical benefits.

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References

Sah J, Ito H, Kolli B, Peterson D, Sassa S, Chang K . Genetic rescue of Leishmania deficiency in porphyrin biosynthesis creates mutants suitable for analysis of cellular events in uroporphyria and for photodynamic therapy. J Biol Chem. 2002; 277(17):14902-9. DOI: 10.1074/jbc.M200107200. View

Bissonnette R, Tremblay J, Juzenas P, Boushira M, Lui H . Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques. J Invest Dermatol. 2002; 119(1):77-83. DOI: 10.1046/j.1523-1747.2002.01827.x. View

Gollnick H, Krautheim A . Topical treatment in acne: current status and future aspects. Dermatology. 2003; 206(1):29-36. DOI: 10.1159/000067820. View

Zouboulis C, Piquero-Martin J . Update and future of systemic acne treatment. Dermatology. 2003; 206(1):37-53. DOI: 10.1159/000067821. View

Alberola J, Rodriguez A, Francino O, Roura X, Rivas L, Andreu D . Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis. Antimicrob Agents Chemother. 2004; 48(2):641-3. PMC: 321547. DOI: 10.1128/AAC.48.2.641-643.2004. View

De Almeida M, Vilhena V, Barral A, Barral-Netto M . Leishmanial infection: analysis of its first steps. A review. Mem Inst Oswaldo Cruz. 2004; 98(7):861-70. DOI: 10.1590/s0074-02762003000700001. View

Pollock B, Turner D, Stringer M, Bojar R, Goulden V, Stables G . Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol. 2004; 151(3):616-22. DOI: 10.1111/j.1365-2133.2004.06110.x. View

Katsambas A, Papakonstantinou A . Acne: systemic treatment. Clin Dermatol. 2004; 22(5):412-8. DOI: 10.1016/j.clindermatol.2004.03.014. View

Radakovic-Fijan S, Blecha-Thalhammer U, Schleyer V, Szeimies R, Zwingers T, Honigsmann H . Topical aminolaevulinic acid-based photodynamic therapy as a treatment option for psoriasis? Results of a randomized, observer-blinded study. Br J Dermatol. 2005; 152(2):279-83. DOI: 10.1111/j.1365-2133.2004.06363.x. View

10.

Smucler R, Jatsova E . Comparative study of aminolevulic acid photodynamic therapy plus pulsed dye laser versus pulsed dye laser alone in treatment of viral warts. Photomed Laser Surg. 2005; 23(2):202-5. DOI: 10.1089/pho.2005.23.202. View

11.

Zakhary K, Ellis D . Applications of aminolevulinic Acid-based photodynamic therapy in cosmetic facial plastic practices. Facial Plast Surg. 2005; 21(2):110-6. DOI: 10.1055/s-2005-872411. View

12.

Fransson J, Ros A . Clinical and immunohistochemical evaluation of psoriatic plaques treated with topical 5-aminolaevulinic acid photodynamic therapy. Photodermatol Photoimmunol Photomed. 2005; 21(6):326-32. DOI: 10.1111/j.1600-0781.2005.00182.x. View

13.

Smits T, Kleinpenning M, van Erp P, van de Kerkhof P, Gerritsen M . A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis. Br J Dermatol. 2006; 155(2):429-36. DOI: 10.1111/j.1365-2133.2006.07290.x. View

14.

Horfelt C, Funk J, Frohm-Nilsson M, Wiegleb Edstrom D, Wennberg A . Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acne vulgaris: results of a randomized, controlled study. Br J Dermatol. 2006; 155(3):608-13. DOI: 10.1111/j.1365-2133.2006.07340.x. View

15.

Kosaka S, Akilov O, ORiordan K, Hasan T . A mechanistic study of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis. J Invest Dermatol. 2007; 127(6):1546-9. DOI: 10.1038/sj.jid.5700719. View

16.

Degitz K, Placzek M, Borelli C, Plewig G . Pathophysiology of acne. J Dtsch Dermatol Ges. 2007; 5(4):316-23. DOI: 10.1111/j.1610-0387.2007.06274.x. View

17.

Horfelt C, Stenquist B, Larko O, Faergemann J, Wennberg A . Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. Acta Derm Venereol. 2007; 87(4):325-9. DOI: 10.2340/00015555-0243. View

18.

Wang Y, Tay Y, Kwok C, Tan E . Photodynamic therapy with 20% aminolevulinic acid for the treatment of recalcitrant viral warts in an Asian population. Int J Dermatol. 2007; 46(11):1180-4. DOI: 10.1111/j.1365-4632.2007.03210.x. View

19.

Boehncke W, Schon M . Animal models of psoriasis. Clin Dermatol. 2007; 25(6):596-605. DOI: 10.1016/j.clindermatol.2007.08.014. View

20.

Webster G, Graber E . Antibiotic treatment for acne vulgaris. Semin Cutan Med Surg. 2008; 27(3):183-7. DOI: 10.1016/j.sder.2008.07.001. View