» Articles » PMID: 29321181

Mechanisms of Erythrocyte Development and Regeneration: Implications for Regenerative Medicine and Beyond

Overview
Journal Development
Specialty Biology
Date 2018 Jan 12
PMID 29321181
Citations 26
Authors
Affiliations
Soon will be listed here.
Abstract

Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed 'stress erythropoiesis' to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

Citing Articles

Exploring the Molecular Characteristics and Role of PDGFB in Testis and Epididymis Development of Tibetan Sheep.

Chen H, Pu L, Tian C, Qi X, Song J, Liao Y Vet Sci. 2024; 11(6).

PMID: 38922013 PMC: 11209412. DOI: 10.3390/vetsci11060266.


Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia.

Yu S, Ye Y, Wuren T, Yi H Front Physiol. 2024; 15:1359357.

PMID: 38426208 PMC: 10902074. DOI: 10.3389/fphys.2024.1359357.


Characterization, dose dependent assessment of hepatorenal oxidative stress, hematological parameters and histopathological divulging of the hepatic damages induced by Zinc oxide nanoparticles (ZnO-NPs) in adult male Sprague Dawley rats.

Kausar S, Jabeen F, Latif M, Asad M Saudi J Biol Sci. 2023; 30(9):103745.

PMID: 37588571 PMC: 10425408. DOI: 10.1016/j.sjbs.2023.103745.


Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function.

Zhou Y, Dogiparthi V, Ray S, Schaefer M, Harris H, Rowley M Blood Adv. 2023; 7(20):6325-6338.

PMID: 36809789 PMC: 10587717. DOI: 10.1182/bloodadvances.2022009163.


The role of erythrocytes and erythroid progenitor cells in tumors.

Zhang H, Wan G, Wang Y, Chen W, Guan J Open Life Sci. 2022; 17(1):1641-1656.

PMID: 36567722 PMC: 9755711. DOI: 10.1515/biol-2022-0102.


References
1.
Poletto V, Rosti V, Villani L, Catarsi P, Carolei A, Campanelli R . A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation. Blood. 2012; 120(15):3112-7. PMC: 3628115. DOI: 10.1182/blood-2012-05-433466. View

2.
Zhu B, McLaughlin S, Na R, Liu J, Cui Y, Martin C . Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008; 112(5):2071-80. PMC: 2518907. DOI: 10.1182/blood-2007-12-127480. View

3.
Lahti L, Haugas M, Tikker L, Airavaara M, Voutilainen M, Anttila J . Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei. Development. 2016; 143(3):516-29. DOI: 10.1242/dev.129957. View

4.
Carey A, Edwards 5th D, Eide C, Newell L, Traer E, Medeiros B . Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia. Cell Rep. 2017; 18(13):3204-3218. PMC: 5437102. DOI: 10.1016/j.celrep.2017.03.018. View

5.
Kang Y, Sanalkumar R, OGeen H, Linnemann A, Chang C, Bouhassira E . Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol. 2011; 32(1):226-39. PMC: 3255705. DOI: 10.1128/MCB.06166-11. View