Inactivation of Gamma-aminobutyric Acid Aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic Acid Does Not Proceed by the Expected Aromatization Mechanism

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2003 Dec 20

PMID 14684328

Citations 5

Authors

Mengmeng Fu

Richard B Silverman

Affiliations

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Abstract

Inactivation of pyridoxal 5'-phosphate (PLP)-dependent gamma-aminobutryic acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (SADFA) gives pyridoxamine 5'-phosphate, not the expected SADFA-PLP aromatization product. Inactivation appears to proceed by a Michael addition/hydrolysis mechanism instead.

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