» Articles » PMID: 14624363

The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport ProteinsIntroduction

Overview
Journal Pflugers Arch
Specialty Physiology
Date 2003 Nov 19
PMID 14624363
Citations 341
Authors
Affiliations
Soon will be listed here.
Abstract

The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/). Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/slctable.asp) that gives the latest updates for the SLC families and their members as well as relevant links to gene databases and reviews in the literature. A list of all currently known SLC families, a discussion of additional SLC families and family members as well as a brief summary of non-SLC transporter genes is included in this introduction.

Citing Articles

Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.

Liao Y, Chen J, Yao H, Zheng T, Tu J, Chen W J Transl Med. 2025; 23(1):103.

PMID: 39844299 PMC: 11752724. DOI: 10.1186/s12967-025-06086-1.


ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches.

Elbahnsi A, Dudas B, Callebaut I, Hinzpeter A, Miteva M Pharmaceuticals (Basel). 2025; 17(12.

PMID: 39770445 PMC: 11676857. DOI: 10.3390/ph17121602.


Energetics of substrate transport in proton-dependent oligopeptide transporters.

Selvam B, Chiang N, Shukla D Commun Chem. 2024; 7(1):309.

PMID: 39741165 PMC: 11688431. DOI: 10.1038/s42004-024-01398-7.


Role of solute carrier transporters in ovarian cancer (Review).

Quaresima B, Scicchitano S, Faniello M, Mesuraca M Int J Mol Med. 2024; 55(2).

PMID: 39611477 PMC: 11637498. DOI: 10.3892/ijmm.2024.5465.


Pharmacometabolomics Approach to Explore Pharmacokinetic Variation and Clinical Characteristics of a Single Dose of Desvenlafaxine in Healthy Volunteers.

Reis Silveira A, Sanchez-Vinces S, Silva A, Sanchez-Luquez K, Garcia P, Garcia C Pharmaceutics. 2024; 16(11).

PMID: 39598509 PMC: 11597518. DOI: 10.3390/pharmaceutics16111385.


References
1.
ORegan S, Meunier F . Selection and characterization of the choline transport mutation suppressor from Torpedo electric lobe, CTL1. Neurochem Res. 2003; 28(3-4):551-5. DOI: 10.1023/a:1022877524469. View

2.
Uhl J, Penzel R, Sergi C, Kopitz J, Otto H, Cantz M . Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient. FEBS Lett. 2002; 521(1-3):19-23. DOI: 10.1016/s0014-5793(02)02748-5. View

3.
Yu F, Catterall W . Overview of the voltage-gated sodium channel family. Genome Biol. 2003; 4(3):207. PMC: 153452. DOI: 10.1186/gb-2003-4-3-207. View

4.
Ishida N, Kawakita M . Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch. 2003; 447(5):768-75. DOI: 10.1007/s00424-003-1093-0. View

5.
Cox D, Moore S . Copper transporting P-type ATPases and human disease. J Bioenerg Biomembr. 2003; 34(5):333-8. DOI: 10.1023/a:1021293818125. View