EFFECTS OF PROLONGED ETHANOL INTAKE: PRODUCTION OF FATTY LIVER DESPITE ADEQUATE DIETS

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1965 Jun 1

PMID 14322019

Citations 111

Authors

C S Lieber

D P Jones

L M DECARLI

Affiliations

Soon will be listed here.

Citing Articles

Alcohol Use Disorder and Alcohol-Associated Liver Disease: New Definitions, Screening, and Treatment.

Roldan G, Tricarico C, Brown Jr R Gastroenterol Hepatol (N Y). 2025; 20(11):662-671.

PMID: 39886332 PMC: 11775998.

Experimental In Vivo Toxicity Models for Alcohol Toxicity.

Yoladi F, Burmaoglu E, Palabiyik S Eurasian J Med. 2024; 55(1):82-90.

PMID: 39109811 PMC: 11075036. DOI: 10.5152/eurasianjmed.2023.23345.

Tumor necrosis factor-inducible gene 6 protein and its derived peptide ameliorate liver fibrosis by repressing CD44 activation in mice with alcohol-related liver disease.

Han J, Lee C, Jeong H, Jeon S, Lee M, Lee H J Biomed Sci. 2024; 31(1):54.

PMID: 38790021 PMC: 11127441. DOI: 10.1186/s12929-024-01042-5.

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1.

Rodriguez-Agudo R, Gonzalez-Recio I, Serrano-Macia M, Bravo M, Petrov P, Blaya D JHEP Rep. 2024; 6(1):100918.

PMID: 38192540 PMC: 10772393. DOI: 10.1016/j.jhepr.2023.100918.

Steroid use in alcohol-associated hepatitis: A history.

Blaney H, Tapper E Clin Liver Dis (Hoboken). 2023; 21(5):143-146.

PMID: 37936926 PMC: 10627589. DOI: 10.1097/CLD.0000000000000054.

References

Summerskill W, WOLFE S, Davidson C . Response to alcohol in chronic alcoholics with liver disease; clinical, pathological, and metabolic changes. Lancet. 1957; 272(6964):335-40. DOI: 10.1016/s0140-6736(57)90402-6. View

MORGAN A, BRINNER L, PLAA C, Stone M . Utilization of calories from alcohol and wines and their effects on cholesterol metabolism. Am J Physiol. 1957; 189(2):290-6. DOI: 10.1152/ajplegacy.1957.189.2.290. View

Lieber C . PATHOGENESIS OF HEPATIC STEATOSIS. Gastroenterology. 1963; 45:760-4. View

BEST C, HARTROFT W . Liver damage produced by feeding alcohol or sugar and its prevention by choline. Br Med J. 1949; 2(4635):1002-6, pl. PMC: 2051633. DOI: 10.1136/bmj.2.4635.1001. View

Lieber C, Schmid R . The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest. 1961; 40:394-9. PMC: 290732. DOI: 10.1172/JCI104266. View

di Luzio N . Effect of acute ethanol intoxication on liver and plasma lipid fractions of the rat. Am J Physiol. 1958; 194(3):453-6. DOI: 10.1152/ajplegacy.1958.194.3.453. View

Lieber C, Davidson C . Some metabolic effects of ethyl alcohol. Am J Med. 1962; 33:319-27. DOI: 10.1016/0002-9343(62)90229-2. View

REBOUCAS G, Isselbacher K . Studies on the pathogenesis of the ethanol-induced fatty liver. I. Synthesis and oxidation of fatty acids by the liver. J Clin Invest. 1961; 40:1355-62. PMC: 292503. DOI: 10.1172/JCI104366. View

Schapiro R, DRUMMEY G, Shimizu Y, Isselbacher K . STUDIES ON THE PATHOGENESIS OF THE ETHANOL-INDUCED FATTY LIVER. II. EFFECT OF ETHANOL ON PALMITATE-1-C-14 METABOLISM BY THE ISOLATED PERFUSED RAT LIVER. J Clin Invest. 1964; 43:1338-47. PMC: 289609. DOI: 10.1172/JCI105009. View

10.

Losowsky M, Jones D, Davidson C, Lieber C . STUDIES OF ALCOHOLIC HYPERLIPEMIA AND ITS MECHANISM. Am J Med. 1963; 35:794-803. DOI: 10.1016/0002-9343(63)90241-9. View

11.

KLATSKIN G, KREHL W, CONN H . The effect of alcohol on the choline requirement. I. Changes in the rat's liver following prolonged ingestion of alcohol. J Exp Med. 1954; 100(6):605-14. PMC: 2136402. DOI: 10.1084/jem.100.6.605. View

12.

KLATSKIN G, GEWIN H, KREHL W . Effects of prolonged alcohol ingestion on the liver of the rat under conditions of controlled adequate dietary intake. Yale J Biol Med. 1951; 23(4):317-31. PMC: 2599056. View

13.

Jones D, Losowsky M, Davidson C, Lieber C . EFFECTS OF ETHANOL ON PLASMA LIPIDS IN MAN. J Lab Clin Med. 1963; 62:675-82. View

14.

ERENOGLU E, EDREIRA J, PATEK Jr A . OBSERVATIONS ON PATIENTS WITH LAENNEC'S CIRRHOSIS RECEIVING ALCOHOL WHILE ON CONTROLLED DIETS. Ann Intern Med. 1964; 60:814-23. DOI: 10.7326/0003-4819-60-5-814. View

15.

Van Handel E, ZILVERSMIT D . Micromethod for the direct determination of serum triglycerides. J Lab Clin Med. 1957; 50(1):152-7. View

16.

MALLOV S, Bloch J . Role of hypophysis and adrenals in fatty infiltration of liver resulting from acute ethanol intoxication. Am J Physiol. 1956; 184(1):29-34. DOI: 10.1152/ajplegacy.1955.184.1.29. View

17.

KLATSKIN G . Alcohol and its relation to liver damage. Gastroenterology. 1961; 41:443-51. View

18.

SIDRANSKY H, Farber E . Sex difference in induction of periportal fatty liver by methionine deficiency in the rat. Proc Soc Exp Biol Med. 1958; 98(2):293-7. DOI: 10.3181/00379727-98-24022. View

19.

Folch J, Lees M, SLOANE STANLEY G . A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957; 226(1):497-509. View

20.

MALLOV S . Effect of chronic ethanol intoxication on liver lipid content of rats. Proc Soc Exp Biol Med. 1955; 88(2):246-9. DOI: 10.3181/00379727-88-21553. View