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Protection Against Brucella Melitensis or Brucella Abortus in Mice with Immunoglobulin G (IgG), IgA, and IgM Monoclonal Antibodies Specific for a Common Epitope Shared by the Brucella A and M Smooth Lipopolysaccharides

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1992 Jan 1
PMID 1370276
Citations 32
Authors
A Cloeckaert
I Jacques
P de Wergifosse
G Dubray
J N Limet
Affiliations
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Abstract

Mice passively immunized prior to a challenge infection with immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) specific for a common epitope of both A- and M-dominant strains had viable Brucella abortus 544 or Brucella melitensis H38 counts in the spleen reduced to the same extent as did mice passively immunized with MAbs specific for either the A or the M epitope. The IgA MAb was not effective.

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References
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