The Role of Nitric Oxide As an Endogenous Regulator of Platelet and Neutrophil Activation Within the Pulmonary Circulation of the Rabbit

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1991 Mar 1

PMID 1364849

Citations 27

Authors

G R May

P Crook

P K Moore

C P Page

Affiliations

Soon will be listed here.

Abstract

1. Intravenous (i.v.) administration of adenosine diphosphate (ADP), platelet activating factor (PAF) and thrombin induced a dose-related accumulation of 111indium-labelled platelets within the thoracic region of anaesthetized rabbits. 2. I.v. administration of the inhibitor of NO biosynthesis, L-NG-nitro arginine methyl ester (L-NAME; 10 mg kg-1) significantly potentiated the peak platelet accumulation induced by ADP, PAF and thrombin. Additionally L-NAME prolonged the disaggregation of platelets in comparison to D-NAME (10 mg kg-1). Such changes were reversible by the administration of L-arginine (900 mg kg-1). 3. I.v. administration of PAF induced a small accumulation of 111indium-labelled neutrophils within the pulmonary circulation which could be greatly potentiated by pretreatment of the animals with L-NAME. In contrast, thrombin administration did not cause significant accumulation of 11indium-labelled erythrocytes in the pulmonary circulation of anaesthetized rabbits. 4. Intracarotid (i.c.) administration of thrombin induced a marked accumulation of radiolabelled platelets within the cranial vasculature which was not potentiated by the prior administration of L-NAME (at either 10 mg kg-1 or 100 mg kg-1). 5. These results suggest that endogenous NO may regulate platelet and polymorphonuclear leukocyte activation within the pulmonary but not the cerebral circulation of rabbits.

Citing Articles

Effects of prenatal hypoxia on fetal sheep heart development and proteomics analysis.

Li H, Hu J, Liu Y, Wang X, Tang S, Chen X Int J Clin Exp Pathol. 2020; 11(4):1909-1922.

PMID: 31938297 PMC: 6958198.

Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals.

Badran M, Golbidi S, Ayas N, Laher I Sleep Disord. 2015; 2015:387801.

PMID: 26064689 PMC: 4438195. DOI: 10.1155/2015/387801.

New perspectives of nitric oxide donors in cardiac arrest and cardiopulmonary resuscitation treatment.

Kruzliak P, Pechanova O, Kara T Heart Fail Rev. 2013; 19(3):383-90.

PMID: 23712508 PMC: 3976759. DOI: 10.1007/s10741-013-9397-4.

Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage.

Silva R, Santos G, Nicolau L, Lucetti L, Santana A, Chaves L Mar Drugs. 2011; 9(11):2188-2200.

PMID: 22163181 PMC: 3229230. DOI: 10.3390/md9112188.

Nasal hyperreactivity and inflammation in allergic rhinitis.

Garrelds I, Veld C, Wijk R, Zijlstra F Mediators Inflamm. 1996; 5(2):79-94.

PMID: 18475703 PMC: 2365776. DOI: 10.1155/S0962935196000142.

References

Radomski M, Palmer R, Moncada S . Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987; 2(8567):1057-8. DOI: 10.1016/s0140-6736(87)91481-4. View

Tayeh M, Marletta M . Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. J Biol Chem. 1989; 264(33):19654-8. View

Gibson A, Mirzazadeh S, Hobbs A, Moore P . L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br J Pharmacol. 1990; 99(3):602-6. PMC: 1917344. DOI: 10.1111/j.1476-5381.1990.tb12976.x. View

Moore P, Al-Swayeh O, Chong N, Evans R, Gibson A . L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol. 1990; 99(2):408-12. PMC: 1917379. DOI: 10.1111/j.1476-5381.1990.tb14717.x. View

May G, Herd C, Butler K, Page C . Radioisotopic model for investigating thromboembolism in the rabbit. J Pharmacol Methods. 1990; 24(1):19-35. DOI: 10.1016/0160-5402(90)90046-n. View

Radomski M, Palmer R, Moncada S . An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990; 87(13):5193-7. PMC: 54288. DOI: 10.1073/pnas.87.13.5193. View

Loskutoff D, Edgington T . Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci U S A. 1977; 74(9):3903-7. PMC: 431779. DOI: 10.1073/pnas.74.9.3903. View

Bhardwaj R, Page C, May G, Moore P . Endothelium-derived relaxing factor inhibits platelet aggregation in human whole blood in vitro and in the rat in vivo. Eur J Pharmacol. 1988; 157(1):83-91. DOI: 10.1016/0014-2999(88)90474-8. View

Azuma H, Ishikawa M, Sekizaki S . Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol. 1986; 88(2):411-5. PMC: 1916833. DOI: 10.1111/j.1476-5381.1986.tb10218.x. View

10.

Hogan J, Lewis M, Henderson A . In vivo EDRF activity influences platelet function. Br J Pharmacol. 1988; 94(4):1020-2. PMC: 1854093. DOI: 10.1111/j.1476-5381.1988.tb11616.x. View

11.

McCall T, Boughton-Smith N, Palmer R, Whittle B, Moncada S . Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. Biochem J. 1989; 261(1):293-6. PMC: 1138817. DOI: 10.1042/bj2610293. View

12.

Salvemini D, Nucci G, Gryglewski R, Vane J . Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc Natl Acad Sci U S A. 1989; 86(16):6328-32. PMC: 297832. DOI: 10.1073/pnas.86.16.6328. View

13.

Boje K, Fung H . Endothelial nitric oxide generating enzyme(s) in the bovine aorta: subcellular location and metabolic characterization. J Pharmacol Exp Ther. 1990; 253(1):20-6. View

14.

Thiemermann C, May G, Page C, Vane J . Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets. Br J Pharmacol. 1990; 99(2):303-8. PMC: 1917386. DOI: 10.1111/j.1476-5381.1990.tb14699.x. View

15.

Chester A, ONeil G, Moncada S, Tadjkarimi S, Yacoub M . Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries. Lancet. 1990; 336(8720):897-900. DOI: 10.1016/0140-6736(90)92269-n. View

16.

Knowles R, Palacios M, Palmer R, Moncada S . Kinetic characteristics of nitric oxide synthase from rat brain. Biochem J. 1990; 269(1):207-10. PMC: 1131553. DOI: 10.1042/bj2690207. View

17.

Moncada S, Gryglewski R, Bunting S, Vane J . An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976; 263(5579):663-5. DOI: 10.1038/263663a0. View

18.

Page C, Paul W, Morley J . An in vivo model for studying platelet aggregation and disaggregation. Thromb Haemost. 1982; 47(3):210-3. View

19.

FURCHGOTT R, Zawadzki J . The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980; 288(5789):373-6. DOI: 10.1038/288373a0. View

20.

Rosenblum W, Nelson G, Povlishock J . Laser-induced endothelial damage inhibits endothelium-dependent relaxation in the cerebral microcirculation of the mouse. Circ Res. 1987; 60(2):169-76. DOI: 10.1161/01.res.60.2.169. View