Monoclonal Antibodies for the Identification of Herpesvirus Simiae (B Virus)

Overview

Journal Arch Virol

Specialty Microbiology

Date 1992 Jan 1

PMID 1314049

Citations 9

Authors

L M Cropper

D N Lees

R Patt

I R Sharp

D Brown

Affiliations

Soon will be listed here.

Abstract

To differentiate between B virus and HSV isolates from monkeys and man monoclonal antibodies (mabs) were produced to herpesvirus simiae (B virus) and herpes simplex type 1 and 2 (HSV-1 and HSV-2). Mabs were tested by indirect immunofluorescence (IFAT) for reactivity against herpesviruses from Asiatic monkeys (B virus), African monkeys (SA 8 virus), and man (HSV-1, HSV-2, varicella-zoster virus, cytomegalovirus, and Epstein-Barr virus). Mabs could be divided into groups A-E displaying specific reactivity for B virus (A); reactivity with both B virus and SA 8 but not HSV (B); reactivity with B virus, SA 8 virus and HSV strains (C); specific reactivity with HSV-1 (D); and specific reactivity with HSV-2 (E). Two of the B virus specific mabs were able to differentiate between cynomolgus and rhesus strains of B virus. None of the mabs reacted with human varicella-zoster virus, cytomegalovirus, or Epstein-Barr virus. A panel of mabs for the unequivocal identification of B virus isolates from monkey or man is proposed.

Citing Articles

Towards a comprehensive view of the herpes B virus.

Lu J, Long Y, Sun J, Gong L Front Immunol. 2023; 14:1281384.

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Questioning the Extreme Neurovirulence of Monkey B Virus .

Eberle R, Jones-Engel L Adv Virol. 2018; 2018:5248420.

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Understanding Primate Herpesviruses.

Eberle R, Jones-Engel L J Emerg Dis Virol. 2018; 3(1).

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Identification of unique B virus (Macacine Herpesvirus 1) epitopes of zoonotic and macaque isolates using monoclonal antibodies.

Katz D, Shi W, Gowda M, Vasireddi M, Patrusheva I, Seoh H PLoS One. 2017; 12(8):e0182355.

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Monkey B virus (Cercopithecine herpesvirus 1).

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