Questioning the Extreme Neurovirulence of Monkey B Virus

Overview

Journal Adv Virol

Publisher Wiley

Specialty Microbiology

Date 2018 Apr 19

PMID 29666644

Citations 12

Authors

R Eberle

L Jones-Engel

Affiliations

Soon will be listed here.

Abstract

Monkey B virus ( 1; BV) occurs naturally in macaques of the genus which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. However, BV is notorious for its neurovirulence since zoonotic infections are serious, usually involving the central nervous system, and are frequently fatal. Little is known about factors underlying the extreme neurovirulence of BV in humans. Here we review what is actually known about the molecular biology of BV and viral factors affecting its neurovirulence. Based on what is known about related herpesviruses, areas for future research that may elucidate mechanisms underlying the neurovirulence of this intriguing virus are also reviewed.

Citing Articles

Towards a comprehensive view of the herpes B virus.

Lu J, Long Y, Sun J, Gong L Front Immunol. 2023; 14:1281384.

PMID: 38035092 PMC: 10687423. DOI: 10.3389/fimmu.2023.1281384.

Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis.

Ponzetto E, Delhez Q, Hoppenbrouwers M, De Schryver N, Serck N, Dugernier T Am J Trop Med Hyg. 2023; 109(6):1277-1281.

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A Review on Zoonotic Pathogens Associated with Non-Human Primates: Understanding the Potential Threats to Humans.

Jiang X, Fan Z, Li S, Yin H Microorganisms. 2023; 11(2).

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Fatal progressive ascending encephalomyelitis caused by herpes B virus infection: first case from China.

Zhang T, Zhao Z, Sun X, Xie M, Liu F, Zhang Y World J Emerg Med. 2022; 13(4):330-333.

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Simplexviruses Successfully Adapt to Their Host by Fine-Tuning Immune Responses.

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