A Follow-up Study of Children Born After Diode Laser Assisted Hatching

This follow-up study of children born after laser assisted hatching (LAH) with a non-contact laser aims to compile data on karyotypes, deliveries, congenital malformations and growth parameters to evaluate the safety of this new technique. The study design consisted of karyotyping and completion of a standardized questionnaire. Data were analyzed for the first 134 children born after LAH. Indication for LAH were the age (over 35 years) (group I), previously minimum three unsuccessful IVF-ET treatment cycles (group II) and age >35 years with at least three unsuccessful IVF cycles (group III). In our study group of 134 babies we found no increase in the major congenital malformation rate (2.2%) which is comparable with the major congenital malformation rate (3%) among all deliveries at our hospital. No increase in chromosomal aberrations could be observed. Neither could we observe a difference in minor congenital malformations between the LAH treated group and all deliveries at our hospital (10.4% versus 11.1%). On this limited number of children born after LAH there was neither evidence of an increased incidence of chromosomal aberrations nor of congenital malformations.