Laser-assisted Hatching on Clinical and Neonatal Outcomes in Patients Undergoing Single Vitrified Blastocyst Transfer: A Propensity Score-matched Study

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2021 Apr 14

PMID 33850451

Citations 6

Authors

Yuji Endo

Shingo Mitsuhata

Momoko Hayashi

Yoshitaka Fujii

Hiroaki Motoyama

Affiliations

Soon will be listed here.

Abstract

Purpose: This study determined the effect of laser-assisted hatching on the clinical and neonatal outcomes of single vitrified blastocyst transfer.

Methods: From June 2014 to March 2018, 289 matched pairs after propensity score matching were analyzed. During the blastocyst warming procedure, a small section of the zona pellucida area in the empty perivitelline space was sliced off using multiple laser beams. The clinical and neonatal outcomes of the laser-treated group and non-treatment control were analyzed.

Results: In the laser-assisted hatching group, significantly higher rates of clinical pregnancy (40.8% vs 29.4%, < .01) and live delivery (34.3% vs 22.5%, < .01) were observed compared to the control group. Other variables such as the average gestational weeks, the sex of the baby, birthweight, or congenital malformations were found to have no significant differences in neonatal outcomes. Moreover, all babies were singleton live births.

Conclusions: Single vitrified blastocyst transfer treated with laser-assisted hatching increases the live birth rate and has no adverse effects on neonatal outcomes.

Citing Articles

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Two laser-assisted hatching methods of embryos in ART: a systematic review and meta-analysis.

Chen K, Gao M, Wu Y, Hu Z, Tang L, Li M BMC Pregnancy Childbirth. 2024; 24(1):300.

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Clinical and neonatal outcomes of complete zona pellucida removal by laser-assisted hatching after single vitrified-warmed blastocyst transfer.

Baatarsuren M, Jamiyansuren J, Ganbaatar C, Sengebaljir D, Erdenekhuyag B, Enkhbaatar S Lasers Med Sci. 2024; 39(1):51.

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The Current Practice of Assisted Hatching for Embryos in Fertility Centres: a General Survey.

Liu Y, Jones C, Coward K Reprod Sci. 2022; 29(9):2664-2673.

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Efficiency and safety of laser-assisted hatching on vitrified-warmed blastocyst transfer cycles: a prospective control trial.

Yin C, Li L, Ma S, Zhao H, Xu L, Li C Lasers Med Sci. 2021; 37(3):1931-1942.

PMID: 34802083 DOI: 10.1007/s10103-021-03453-4.

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