Genetic Interaction Between Wnt/beta-catenin and BMP Receptor Signaling During Formation of the AER and the Dorsal-ventral Axis in the Limb

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2003 Aug 19

PMID 12923052

Citations 63

Authors

Natalia Soshnikova

Dietmar Zechner

Joerg Huelsken

Yuji Mishina

Richard R Behringer

Makoto M Taketo

E Bryan Crenshaw 3rd

Walter Birchmeier

Affiliations

Soon will be listed here.

Abstract

By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling.

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