Walter Birchmeier
Overview
Explore the profile of Walter Birchmeier including associated specialties, affiliations and a list of published articles.
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Articles
120
Citations
13322
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Recent Articles
1.
Myszczyszyn A, Popp O, Kunz S, Sporbert A, Jung S, Penning L, et al.
PLoS One
. 2024 Mar;
19(3):e0282938.
PMID: 38512983
Previously, we found that Wnt and Notch signaling govern stem cells of clear cell kidney cancer (ccRCC) in patients. To mimic stem cell responses in the normal kidney in vitro...
2.
Kamdem N, Roske Y, Kovalskyy D, Platonov M, Balinskyi O, Kreuchwig A, et al.
Magn Reson (Gott)
. 2023 Oct;
2(1):355-374.
PMID: 37904770
Dishevelled (Dvl) proteins are important regulators of the Wnt signalling pathway, interacting through their PDZ domains with the Wnt receptor Frizzled. Blocking the Dvl PDZ-Frizzled interaction represents a potential approach...
3.
Lluch A, Latorre J, Serena-Maione A, Espadas I, Caballano-Infantes E, Moreno-Navarrete J, et al.
Nat Commun
. 2023 Aug;
14(1):5106.
PMID: 37607954
Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to its role in...
4.
Ventura P, Gakovic M, Fischer B, Spinelli L, Rota G, Pathak S, et al.
EMBO Rep
. 2022 Oct;
23(11):e55399.
PMID: 36194675
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD-1. Blockade of PD-1 leads to T cell reinvigoration and is...
5.
Qi J, Cui D, Wu Q, Zhao Q, Chen Z, Li L, et al.
Cancers (Basel)
. 2022 Jul;
14(13).
PMID: 35805009
Metastasis is the main cause of death for patients suffering gastric cancer. Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are critical attributes of metastasis, both of which are regulated...
6.
Heynen G, Lisek K, Vogel R, Wulf-Goldenberg A, Alcaniz J, Montaudon E, et al.
Breast Cancer Res
. 2022 Apr;
24(1):23.
PMID: 35365185
Background: PI3K signaling is frequently activated in breast cancer and is targeted by PI3K inhibitors. However, resistance of tumor cells to PI3K inhibition, often mediated by activated receptor tyrosine kinases,...
7.
Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, et al.
PLoS Genet
. 2021 Dec;
17(12):e1009250.
PMID: 34860830
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone...
8.
Sommariva E, Stadiotti I, Casella M, Catto V, Dello Russo A, Carbucicchio C, et al.
EMBO Mol Med
. 2021 Aug;
13(9):e14365.
PMID: 34337880
Arrhythmogenic cardiomyopathy (ACM) is hallmarked by ventricular fibro-adipogenic alterations, contributing to cardiac dysfunctions and arrhythmias. Although genetically determined (e.g., PKP2 mutations), ACM phenotypes are highly variable. More data on phenotype...
9.
Hammer K, Mustroph J, Stauber T, Birchmeier W, Wagner S, Maier L
PLoS One
. 2021 Jun;
16(6):e0252649.
PMID: 34086773
Arrhythmogenic right ventricular cardiomyopathy is a hereditary, rare disease with an increased risk for sudden cardiac death. The disease-causing mutations are located within the desmosomal complex and the highest incidence...
10.
Heuberger J, Grinat J, Kosel F, Liu L, Kunz S, Vidal R, et al.
Proc Natl Acad Sci U S A
. 2021 May;
118(22).
PMID: 34039707
Specified intestinal epithelial cells reprogram and contribute to the regeneration and renewal of the epithelium upon injury. Mutations that deregulate such renewal processes may contribute to tumorigenesis. Using intestinal organoids,...