JNK Phosphorylation Relieves HDAC3-dependent Suppression of the Transcriptional Activity of C-Jun

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2003 Jul 11

PMID 12853483

Citations 71

Authors

Carsten Weiss

Sandra Schneider

Erwin F Wagner

Xiaohong Zhang

Edward Seto

Dirk Bohmann

Affiliations

Soon will be listed here.

Abstract

The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in c-Jun is essential for signal-dependent target gene activation. We show that c-Jun phosphorylation mediates dissociation of an inhibitory complex, which is associated with histone deacetylase 3 (HDAC3). The subsequent events that ultimately cause increased mRNA synthesis are independent of c-Jun phosphorylation and its interaction with JNK. These findings provide an 'activation by de-repression' model as an explanation for the stimulatory function of JNK on c-Jun.

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