Functional Significance of Histone Deacetylase Diversity

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2001 Mar 16

PMID 11250139

Citations 103

Authors

S Khochbin

A Verdel

C Lemercier

Affiliations

Soon will be listed here.

Abstract

Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuttling process is one of the distinctive characteristics of these enzymes, themselves belonging to structurally and functionally different classes. Considering the specific features of each class of deacetylases, it is possible to determine how each member can contribute to particular cellular functions.

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