Ribosomal Mutations Conferring Resistance to Macrolides in Streptococcus Pneumoniae Clinical Strains Isolated in Germany

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2003 Jun 25

PMID 12821488

Citations 21

Authors

Ralf Rene Reinert

Angela Wild

Peter Appelbaum

Rudolf Lutticken

Murat Yucel Cil

Adnan Al-Lahham

Affiliations

Soon will be listed here.

Abstract

Among a collection of 4281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.

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