Fasting Plasma Glucose Test at the First Prenatal Visit As a Screen for Gestational Diabetes

Overview

Journal Obstet Gynecol

Specialty Gynecology & Obstetrics

Date 2003 Jun 12

PMID 12798525

Citations 20

Authors

David A Sacks

Wansu Chen

Girma Wolde-Tsadik

Thomas A Buchanan

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether the fasting plasma glucose test administered at the first prenatal visit could serve as an efficient screen for gestational diabetes.

Methods: A total of 5557 women not known to have diabetes were offered a fasting plasma glucose test at their first prenatal visit. Results less than 100 mg/dL were blinded. A glucose tolerance test was requested immediately of those whose screening test result was 100-125 mg/dL and of all women not identified as having diabetes by their 23rd gestational week.

Results: A total of 4507 women (81%) complied with the protocol. Of the 302 women found to have gestational diabetes, 46 (15%) were detected before 24 weeks. A false-positive rate of 57% was found at a threshold fasting glucose concentration giving a sensitivity of 80% for the detection of gestational diabetes.

Conclusion: The fasting plasma glucose screening test at the first prenatal visit has good patient compliance. However, its poor specificity (high false-positive rate) makes it an inefficient screening test for gestational diabetes.

Citing Articles

Maternal metabolic factors and the association with gestational diabetes: A systematic review and meta-analysis.

Habibi N, Mousa A, Tay C, Bahri Khomami M, Patten R, Andraweera P Diabetes Metab Res Rev. 2022; 38(5):e3532.

PMID: 35421281 PMC: 9540632. DOI: 10.1002/dmrr.3532.

Early Gestational Diabetes Mellitus: Diagnostic Strategies and Clinical Implications.

Bhattacharya S, Nagendra L, Krishnamurthy A, Lakhani O, Kapoor N, Kalra B Med Sci (Basel). 2021; 9(4).

PMID: 34698239 PMC: 8544345. DOI: 10.3390/medsci9040059.

Can fasting plasma glucose replace oral glucose-tolerance test for diagnosis of gestational diabetes mellitus?.

Babaniamansour S, Aliniagerdroudbari E, Afrakhteh M, Hosseinpanah F, Farzaneh F, Niroomand M Diabetol Int. 2021; 12(3):277-285.

PMID: 34150436 PMC: 8172813. DOI: 10.1007/s13340-020-00484-0.

Accuracy of screening tests for gestational diabetes mellitus in Southeast Asia: A systematic review of diagnostic test accuracy studies.

Lappharat S, Liabsuetrakul T Medicine (Baltimore). 2020; 99(46):e23161.

PMID: 33181689 PMC: 7668444. DOI: 10.1097/MD.0000000000023161.

Diagnostic accuracy of maternal serum multiple marker screening for early detection of gestational diabetes mellitus in the absence of a gold standard test.

Amini M, Kazemnejad A, Zayeri F, Montazeri A, Rasekhi A, Amirian A BMC Pregnancy Childbirth. 2020; 20(1):375.

PMID: 32591020 PMC: 7318500. DOI: 10.1186/s12884-020-03068-7.