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Ruthenium-catalyzed Vinylsilane Synthesis and Cross-coupling As a Selective Approach to Alkenes: Benzyldimethylsilyl As a Robust Vinylmetal Functionality

Overview
Journal Org Lett
Specialties Biochemistry
Chemistry
Date 2003 May 24
PMID 12762680
Citations 33
Authors
Affiliations
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Abstract

[reaction: see text] Ruthenium-catalyzed alkyne hydrosilylation or silyl-alkyne Alder ene reactions provide entry into benzyldimethylsilyl (BDMS)-substituted alkenes. The BDMS-vinylsilanes are further elaborated through mild palladium-catalyzed cross coupling and show significant stability to intervening synthetic operations, including silyl ether deprotection.

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