Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2016 Dec 29

PMID 28027648

Citations 8

Authors

Barry M Trost

Joshua D Knopf

Cheyenne S Brindle

Affiliations

Soon will be listed here.

Abstract

Fostriecin and related natural products present a significant challenge for synthetic chemists due to their structural complexity and chemical sensitivity. This review will chronicle the successful efforts of synthetic chemists in the construction of these biologically active molecules. Key carbon-carbon bond forming reactions will be highlighted, as well as the methods used to install the numerous stereocenters present in this class of compounds.

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