Zachary T Ball
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Explore the profile of Zachary T Ball including associated specialties, affiliations and a list of published articles.
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77
Citations
743
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Recent Articles
1.
Ding Y, Jiang Y, Lorenzo Serrat N, Zhong K, Lan Y, Ball Z
J Am Chem Soc
. 2024 Nov;
146(49):33518-33525.
PMID: 39588935
Pyroglutamate is a cyclic -terminal post-translational modification that occurs in both proteins and peptide hormones. The prevalence and biological roles of pyroglutamate are little understood, in part due to limited...
2.
Ding Y, Pedersen S, Wang Y, Xiao H, Ball Z
Org Lett
. 2024 Jul;
26(31):6608-6613.
PMID: 39072587
We report a minimalist gaseous sulfonyl-chloride-derived reagent for multicomponent bioconjugation with amine, phenol, or aniline reagents to afford urea or carbamate products. With the utilization of a gas-phase reagent for...
3.
Lin A, Ghosh A, Yellen S, Ball Z, Kurti L
J Am Chem Soc
. 2024 Jul;
146(30):21129-21136.
PMID: 39013155
Here, we demonstrate a fundamentally new reactivity of the silyl enol ether functionality utilizing an in situ-generated iodonitrene-like species. The present transformation inserts a nitrogen atom between the silyl enol...
4.
Pogostin B, Wu S, Swierczynski M, Pennington C, Li S, Vohidova D, et al.
bioRxiv
. 2024 Jun;
PMID: 38826442
Maintaining safe and potent pharmaceutical drug levels is often challenging. Multidomain peptides (MDPs) assemble into supramolecular hydrogels with a well-defined, highly porous nanostructure that makes them attractive for drug delivery,...
5.
Ding Y, Pedersen S, Wang H, Xiang B, Wang Y, Yang Z, et al.
Angew Chem Int Ed Engl
. 2024 May;
63(30):e202405344.
PMID: 38753429
Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic stability, limiting conformational flexibility, and altering cellular entry and intracellular localization. The hydrophilic, polyfunctional nature of peptides...
6.
Larkin J, Cheng Z, Arefeayne Y, Segatori L, Jones M, Ball Z
Bioconjug Chem
. 2024 May;
35(6):732-736.
PMID: 38739108
Hybrid materials that combine organic polymers and biomacromolecules offer unique opportunities for precisely controlling 3D chemical environments. Although biological or organic templates have been separately used to control the growth...
7.
Vargas R, Ding Y, Trial H, Qian R, Ball Z
Chem Commun (Camb)
. 2023 Oct;
59(87):13030-13033.
PMID: 37842954
Proximity-induced methodologies for peptide and protein modification have been developed using recognition elements like inhibitors, antibodies, or affinity tags on amino acids. However, the recognition of saccharides for chemical modification...
8.
Larkin J, Mozden S, Chyan Y, Zheng Q, Cherukuri P, Tour J, et al.
ACS Appl Mater Interfaces
. 2023 Sep;
15(39):45601-45605.
PMID: 37724983
Low-temperature plasma is an emerging approach for the treatment of bacterial infections. Nonchemical treatments such as cold plasma offer potential solutions to antibiotic resistance. We investigated the use of laser-induced...
9.
Larkin J, Jayanthi B, Segatori L, Ball Z
Biomacromolecules
. 2023 Apr;
24(5):2196-2202.
PMID: 37084390
The use of transition-metal-mediated boronic acid chemistry presents a novel method of protein immobilization on a solid support. This is a one-step method that site-selectively immobilizes pyroglutamate-histidine (pGH)-tagged proteins. Herein,...
10.
Stevens A, Schafer E, Li M, Terrell M, Rashid R, Paek H, et al.
Cancers (Basel)
. 2023 Feb;
15(4).
PMID: 36831684
Survival of pediatric AML remains poor despite maximized myelosuppressive therapy. The (PJP)-treating medication atovaquone (AQ) suppresses oxidative phosphorylation (OXPHOS) and reduces AML burden in patient-derived xenograft (PDX) mouse models, making...