Pathologic Thrombopoiesis of Rheumatoid Arthritis

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2003 Mar 14

PMID 12634936

Citations 17

Authors

Ihsan Ertenli

Sedat Kiraz

M Akif Ozturk

Ibrahim C Haznedaroglu

Ismail Celik

Meral Calguneri

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis (RA) is frequently complicated by thrombocytosis correlated with disease activity. The exact pathogenetic mechanism(s) that cause increased platelet counts in RA are still unknown. Recent investigations indicate that proinflammatory pleiotropic cytokines of RA also have megakaryocytopoietic/thrombopoietic properties. Moreover, several lineage-dominant hematopoietic cytokines can also act as acute phase responders and contribute to the inflammation. This review focuses on the current literature and our experience regarding the dual relationships of the pathologic thrombopoiesis of RA. Growth factors contributing to it, namely interleukin (IL)-6, IL-11, stem cell factor, leukemia inhibitory factor, granulocyte colony stimulating factor, thrombopoietin (TPO), and the regulation of megakaryocytopoiesis during the inflammatory cascade are reviewed. Some data indicate that thrombopoietin could contribute to the reactive thrombocytosis of RA. In the non-lineage-specific gp130 cytokine family, IL-6 appears to predominate for the induction of megakaryopoiesis. However, other cytokines and growth factors may also contribute to the pathologic megakaryocytopoiesis of RA. Those pleiotropic mediators seem to act in concert to regulate this enigmatic process. Clarification of the pathobiologic basis of thrombopoiesis in RA may improve understanding of the disease pathogenesis and management of the inflammatory thrombocytosis.

Citing Articles

Identifying antinuclear antibody positive individuals at risk for developing systemic autoimmune disease: development and validation of a real-time risk model.

Barnado A, Moore R, Domenico H, Green S, Camai A, Suh A Front Immunol. 2024; 15():1384229.

PMID: 38571954 PMC: 10987951. DOI: 10.3389/fimmu.2024.1384229.

Mean Platelet Volume in a Series of 315 Patients with Rheumatoid Arthritis: Relationship with Disease Characteristics, including Subclinical Atherosclerosis and Cardiovascular Comorbidity.

Gonzalez-Sierra M, Romo-Cordero A, Quevedo-Abeledo J, Quevedo-Rodriguez A, Gomez-Bernal F, de Vera-Gonzalez A Diagnostics (Basel). 2023; 13(20).

PMID: 37892031 PMC: 10605652. DOI: 10.3390/diagnostics13203208.

Clinical prediction rule for bacterial arthritis: Chi-squared automatic interaction detector decision tree analysis model.

Kushiro S, Fukui S, Inui A, Kobayashi D, Saita M, Naito T SAGE Open Med. 2023; 11:20503121231160962.

PMID: 36969723 PMC: 10034275. DOI: 10.1177/20503121231160962.

Is It Possible to Predict Clonal Thrombocytosis in Triple-Negative Patients with Isolated Thrombocytosis Based Only on Clinical or Blood Findings?.

Belcic Mikic T, Vratanar B, Pajic T, Anzej Doma S, Debeljak N, Zupan I J Clin Med. 2021; 10(24).

PMID: 34945099 PMC: 8706709. DOI: 10.3390/jcm10245803.

A Study on Association between Common Haematological Parameters and Disease Activity in Rheumatoid Arthritis.

Talukdar M, Barui G, Adhikari A, Karmakar R, Ghosh U, Das T J Clin Diagn Res. 2017; 11(1):EC01-EC04.

PMID: 28273969 PMC: 5324414. DOI: 10.7860/JCDR/2017/23524.9130.

References

Goddard D, GROSSMAN S, Williams W, Weiner D, Gross J, Eidsvoog K . Regulation of synovial cell growth. Coexpression of transforming growth factor beta and basic fibroblast growth factor by cultured synovial cells. Arthritis Rheum. 1992; 35(11):1296-303. DOI: 10.1002/art.1780351109. View

Jilma B, Eichler H, Vondrovec B, Breiteneder H, Kyrle P, Kitzweger E . Effects of desmopressin on circulating P-selectin. Br J Haematol. 1996; 93(2):432-6. DOI: 10.1046/j.1365-2141.1996.5031040.x. View

Galli S, Tsai M, Wershil B . The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others. Am J Pathol. 1993; 142(4):965-74. PMC: 1886888. View

Rennick D, Yang G, Smith C, Arai N, Takabe Y, Gemmell L . Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells. Proc Natl Acad Sci U S A. 1987; 84(19):6889-93. PMC: 299190. DOI: 10.1073/pnas.84.19.6889. View

Okamoto H, Yamamura M, Morita Y, Harada S, Makino H, Ota Z . The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum. 1997; 40(6):1096-105. DOI: 10.1002/art.1780400614. View

Vollertsen R, Fuster V, Conn D, Luthra H, MCDUFFIE F, BOWIE E . In vivo platelet survival in rheumatoid arthritis. Mayo Clin Proc. 1982; 57(10):620-4. View

Shiozawa S, Shiozawa K, Tanaka Y, Morimoto I, Uchihashi M, Fujita T . Human epidermal growth factor for the stratification of synovial lining layer and neovascularisation in rheumatoid arthritis. Ann Rheum Dis. 1989; 48(10):820-8. PMC: 1003888. DOI: 10.1136/ard.48.10.820. View

Kiener H, Hofbauer R, Tohidast-Akrad M, Walchshofer S, Redlich K, Bitzan P . Tumor necrosis factor alpha promotes the expression of stem cell factor in synovial fibroblasts and their capacity to induce mast cell chemotaxis. Arthritis Rheum. 2000; 43(1):164-74. DOI: 10.1002/1529-0131(200001)43:1<164::AID-ANR21>3.0.CO;2-Z. View

Karakus S, Ozcebe O, Haznedaroglu I, Goker H, Ozatli D, Kosar A . Circulating thrombopoietin in clonal versus reactive thrombocytosis. Hematology. 2002; 7(1):9-12. DOI: 10.1080/10245330290020081. View

10.

Johnston G, Bliss G, Newman P, McEver R . Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes. J Biol Chem. 1990; 265(34):21381-5. View

11.

Moreland L, Gugliotti R, King K, Chase W, Weisman M, Greco T . Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis. Arthritis Res. 2001; 3(4):247-52. PMC: 34114. DOI: 10.1186/ar309. View

12.

Wilder R, Lafyatis R, Roberts A, Case J, Kumkumian G, Sano H . Transforming growth factor-beta in rheumatoid arthritis. Ann N Y Acad Sci. 1990; 593:197-207. DOI: 10.1111/j.1749-6632.1990.tb16112.x. View

13.

Qu Z, Huang X, Ahmadi P, Andresevic J, Planck S, Hart C . Expression of basic fibroblast growth factor in synovial tissue from patients with rheumatoid arthritis and degenerative joint disease. Lab Invest. 1995; 73(3):339-46. View

14.

Schwertschlag U, Trepicchio W, Dykstra K, Keith J, Turner K, Dorner A . Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. Leukemia. 1999; 13(9):1307-15. DOI: 10.1038/sj.leu.2401514. View

15.

Sogo S, Inaba M, Ogata H, Hisha H, Adachi Y, Mori S . Induction of c-kit molecules on human CD34+/c-kit < low cells: evidence for CD34+/c-kit < low cells as primitive hematopoietic stem cells. Stem Cells. 1997; 15(6):420-9. DOI: 10.1002/stem.150420. View

16.

Endresen G . Evidence for activation of platelets in the synovial fluid from patients with rheumatoid arthritis. Rheumatol Int. 1989; 9(1):19-24. DOI: 10.1007/BF00270285. View

17.

Falanga A, Marchetti M, Evangelista V, Manarini S, Oldani E, Giovanelli S . Neutrophil activation and hemostatic changes in healthy donors receiving granulocyte colony-stimulating factor. Blood. 1999; 93(8):2506-14. View

18.

Taki H, Sugiyama E, Kuroda A, Mino T, Kobayashi M . Interleukin-4 inhibits interleukin-11 production by rheumatoid synovial cells. Rheumatology (Oxford). 2000; 39(7):728-31. DOI: 10.1093/rheumatology/39.7.728. View

19.

Dechanet J, Taupin J, Chomarat P, Rissoan M, Moreau J, Banchereau J . Interleukin-4 but not interleukin-10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes. Eur J Immunol. 1994; 24(12):3222-8. DOI: 10.1002/eji.1830241247. View

20.

Arend W, Dayer J . Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum. 1990; 33(3):305-15. DOI: 10.1002/art.1780330302. View