Platelet Function in Rheumatoid Arthritis: Arthritic and Cardiovascular Implications

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2010 Apr 15

PMID 20390282

Citations 53

Authors

Armen Yuri Gasparyan

Antonios Stavropoulos-Kalinoglou

Dimitri P Mikhailidis

Karen M J Douglas

George D Kitas

Affiliations

Soon will be listed here.

Abstract

Patients with rheumatoid arthritis (RA) are at high risk of cardiovascular events. Platelet biomarkers are involved in inflammation, atherosclerosis and thrombosis. Cardiovascular and RA-associated factors can alter the structure and function of platelets, starting from megakaryocytopoiesis. Reactive megakaryocytopoiesis increases circulating platelets count and triggers hyperactivity. Hyperactive platelets target synovial membranes with subsequent local rheumatoid inflammation. Hyperactive platelets interact with other cells, and target the vascular wall. Accumulating evidence suggests that disease modifying anti-rheumatic drugs (DMARD) decrease platelet activity.

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