Developmental Aspects of the Endocrine Pancreas

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2003 Mar 6

PMID 12618555

Citations 8

Authors

Daniel M Kemp

Melissa K Thomas

Joel F Habener

Affiliations

Soon will be listed here.

Citing Articles

Analysis of gene expression on ngn3 gene signaling pathway in endocrine pancreatic cancer.

Nagaraja P, Parashivamurthy K, Sidnal N, Mali S, Nagaraja D, Reddy S Bioinformation. 2013; 9(14):739-47.

PMID: 23976832 PMC: 3746099. DOI: 10.6026/97320630009739.

The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.

Kim S, Rane S Development. 2011; 138(10):1903-12.

PMID: 21490060 PMC: 3082297. DOI: 10.1242/dev.061481.

Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.

Kang H, Kim Y, ZeRuth G, Beak J, Gerrish K, Kilic G Mol Cell Biol. 2009; 29(24):6366-79.

PMID: 19805515 PMC: 2786880. DOI: 10.1128/MCB.01259-09.

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

Anderson K, Torres C, Solomon K, Becker T, Newgard C, Wright C J Biol Chem. 2009; 284(45):31236-48.

PMID: 19759004 PMC: 2781522. DOI: 10.1074/jbc.M109.048694.

Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.

Calderari S, Gangnerau M, Thibault M, Meile M, Kassis N, Alvarez C Diabetologia. 2007; 50(7):1463-71.

PMID: 17476475 DOI: 10.1007/s00125-007-0676-2.

References

Bonner-Weir S . Islet growth and development in the adult. J Mol Endocrinol. 2000; 24(3):297-302. DOI: 10.1677/jme.0.0240297. View

Deutsch G, Jung J, Zheng M, Lora J, Zaret K . A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development. 2001; 128(6):871-81. DOI: 10.1242/dev.128.6.871. View

Sund N, Vatamaniuk M, Casey M, Ang S, Magnuson M, Stoffers D . Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev. 2001; 15(13):1706-15. PMC: 312732. DOI: 10.1101/gad.901601. View

Stoffers D, Kieffer T, Hussain M, Drucker D, Bonner-Weir S, Habener J . Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000; 49(5):741-8. DOI: 10.2337/diabetes.49.5.741. View

Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H . beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 1998; 12(12):1763-8. PMC: 316911. DOI: 10.1101/gad.12.12.1763. View

Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F . Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000; 127(24):5533-40. DOI: 10.1242/dev.127.24.5533. View

Huang H, Liu M, El-Hodiri H, Chu K, Jamrich M, Tsai M . Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol. 2000; 20(9):3292-307. PMC: 85623. DOI: 10.1128/MCB.20.9.3292-3307.2000. View

Bottinger E, Jakubczak J, Roberts I, Mumy M, Hemmati P, Bagnall K . Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas. EMBO J. 1997; 16(10):2621-33. PMC: 1169873. DOI: 10.1093/emboj/16.10.2621. View

Offield M, Jetton T, Labosky P, Ray M, Stein R, Magnuson M . PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996; 122(3):983-95. DOI: 10.1242/dev.122.3.983. View

10.

Sharma A, Zangen D, Reitz P, Taneja M, Lissauer M, Miller C . The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999; 48(3):507-13. DOI: 10.2337/diabetes.48.3.507. View

11.

Gradwohl G, Dierich A, Lemeur M, Guillemot F . neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 2000; 97(4):1607-11. PMC: 26482. DOI: 10.1073/pnas.97.4.1607. View

12.

Rooman I, Lardon J, Bouwens L . Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes. 2002; 51(3):686-90. DOI: 10.2337/diabetes.51.3.686. View

13.

Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S . Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia. 2002; 45(1):85-96. DOI: 10.1007/s125-002-8248-z. View

14.

Chiang C, Litingtung Y, Lee E, Young K, Corden J, Westphal H . Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996; 383(6599):407-13. DOI: 10.1038/383407a0. View

15.

Sander M, Neubuser A, Kalamaras J, Ee H, Martin G, German M . Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 1997; 11(13):1662-73. DOI: 10.1101/gad.11.13.1662. View

16.

Kim S, Hebrok M, Li E, P Oh S, Schrewe H, Harmon E . Activin receptor patterning of foregut organogenesis. Genes Dev. 2000; 14(15):1866-71. PMC: 316826. View

17.

Naya F, Huang H, Qiu Y, Mutoh H, Demayo F, Leiter A . Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997; 11(18):2323-34. PMC: 316513. DOI: 10.1101/gad.11.18.2323. View

18.

Heller R, Stoffers D, Bock T, Svenstrup K, Jensen J, Horn T . Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes. 2001; 50(7):1553-61. DOI: 10.2337/diabetes.50.7.1553. View

19.

Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P . The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 1997; 386(6623):399-402. DOI: 10.1038/386399a0. View

20.

Finegood D, Scaglia L, Bonner-Weir S . Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes. 1995; 44(3):249-56. DOI: 10.2337/diab.44.3.249. View