Delivery of Subunit Vaccines in Maize Seed

Overview

Journal J Control Release

Specialty Pharmacology

Date 2002 Dec 14

PMID 12480322

Citations 34

Authors

Barry J Lamphear

Stephen J Streatfield

Joseph M Jilka

Christopher A Brooks

Donna K Barker

Debra D Turner

Donna E Delaney

Martin Garcia

Barry Wiggins

Susan L Woodard

Elizabeth E Hood

Ian R Tizard

Bruce Lawhorn

John A Howard

Affiliations

Soon will be listed here.

Abstract

The use of recombinant gene technologies by the vaccine industry has revolutionized the way antigens are generated, and has provided safer, more effective means of protecting animals and humans against bacterial and viral pathogens. Viral and bacterial antigens for recombinant subunit vaccines have been produced in a variety of organisms. Transgenic plants are now recognized as legitimate sources for these proteins, especially in the developing area of oral vaccines, because antigens have been shown to be correctly processed in plants into forms that elicit immune responses when fed to animals or humans. Antigens expressed in maize (Zea mays) are particularly attractive since they can be deposited in the natural storage vessel, the corn seed, and can be conveniently delivered to any organism that consumes grain. We have previously demonstrated high level expression of the B-subunit of Escherichia coli heat-labile enterotoxin and the spike protein of swine transmissible gastroenteritis in corn, and have demonstrated that these antigens delivered in the seed elicit protective immune responses. Here we provide additional data to support the potency, efficacy, and stability of recombinant subunit vaccines delivered in maize seed.

Citing Articles

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Maj M, Fake G, Walker J, Saltzman R, Howard J Vaccines (Basel). 2021; 9(12).

PMID: 34960163 PMC: 8706244. DOI: 10.3390/vaccines9121416.

Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult.

Peyret H, Steele J, Jung J, Thuenemann E, Meshcheriakova Y, Lomonossoff G Vaccines (Basel). 2021; 9(7).

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Early Stage Development of a Newcastle Disease Vaccine Candidate in Corn.

Shahid N, Samiullah T, Shakoor S, Latif A, Yasmeen A, Azam S Front Vet Sci. 2020; 7:499.

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Transgenic plants for animal health: plant-made vaccine antigens for animal infectious disease control.

Joensuu J, Niklander-Teeri V, Brandle J Phytochem Rev. 2020; 7(3):553-577.

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State of research in the field of the creation of plant vaccines for veterinary use.

Permyakova N, Uvarova E, Deineko E Russ J Plant Physiol. 2020; 62(1):23-38.

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