Producing Vaccines Against Enveloped Viruses in Plants: Making the Impossible, Difficult

Overview

Journal Vaccines (Basel)

Date 2021 Aug 6

PMID 34358196

Citations 21

Authors

Hadrien Peyret

John F C Steele

Jae-Wan Jung

Eva C Thuenemann

Yulia Meshcheriakova

George P Lomonossoff

Affiliations

Soon will be listed here.

Abstract

The past 30 years have seen the growth of plant molecular farming as an approach to the production of recombinant proteins for pharmaceutical and biotechnological uses. Much of this effort has focused on producing vaccine candidates against viral diseases, including those caused by enveloped viruses. These represent a particular challenge given the difficulties associated with expressing and purifying membrane-bound proteins and achieving correct assembly. Despite this, there have been notable successes both from a biochemical and a clinical perspective, with a number of clinical trials showing great promise. This review will explore the history and current status of plant-produced vaccine candidates against enveloped viruses to date, with a particular focus on virus-like particles (VLPs), which mimic authentic virus structures but do not contain infectious genetic material.

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