A Stereodivergent Approach to Substituted 4-hydroxypiperidines

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2002 Oct 26

PMID 12398517

Citations 3

Authors

Mandy K S Vink

Christien A Schortinghuis

Jordy Luten

Jan H van Maarseveen

Hans E Schoemaker

Henk Hiemstra

Floris P J T Rutjes

Affiliations

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Abstract

A stereodivergent route toward both diastereomeric forms of functionalized 4-hydroxypiperidines has been successfully developed. This route involves biocatalytic generation of the enantiopure starting materials followed by functionalization via N-acyliminium ion-mediated CC-bond formation.

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