Jan H van Maarseveen
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Explore the profile of Jan H van Maarseveen including associated specialties, affiliations and a list of published articles.
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73
Citations
693
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Recent Articles
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Hartendorp A, de Zwart F, Bieraugel H, de Bruin B, Reek J, van Maarseveen J
Org Biomol Chem
. 2021 Dec;
20(3):575-578.
PMID: 34935833
Phenol ester activated dipeptides that are reluctant to ring-close have been cyclised with the aid of sterically shielding metallo-porphyrins avoiding unwanted intermolecular reactions. The binding of ZnTPP to the dipyridine-functionalised...
3.
Pilon S, Jorgensen S, van Maarseveen J
ACS Org Inorg Au
. 2021 Dec;
1(2):37-42.
PMID: 34870280
Despite the advances in the synthesis of mechanically interlocked molecules, a generally applicable approach to interlocked natural products, such as lasso peptides, is yet to be formulated. While amino acid...
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Pilon S, Jorgensen S, van Maarseveen J
Chemistry
. 2020 Nov;
27(7):2310-2314.
PMID: 33200467
After earlier unsuccessful attempts, this work reports the application of covalent templating for the synthesis of mechanically interlocked molecules (MiMs) bearing no supramolecular recognition sites. Two linear strands were covalently...
6.
Cornelissen M, Pilon S, Steemers L, Wanner M, Frolke S, Zuidinga E, et al.
J Org Chem
. 2020 Jan;
85(5):3146-3159.
PMID: 31965801
Incorporation of 2,5-dihydroxyterephthalate as a covalent scaffold in the axis of a 30-membered all-carbon macrocycle provides access to a modular series of rotaxanes. Installment of tethered alkynes or azides onto...
7.
Wanner M, Zuidinga E, Tromp D, Jan Vilim , Jorgensen S, van Maarseveen J
J Org Chem
. 2019 Dec;
85(2):1202-1207.
PMID: 31841007
The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell death. We investigated this process on a synthetic scale, leading to the...
8.
Streefkerk D, Schmidt M, Ippel J, Hackeng T, Nuijens T, Timmerman P, et al.
Org Lett
. 2019 Mar;
21(7):2095-2100.
PMID: 30912446
In Nature, multicyclic peptides constitute a versatile molecule class with various biological functions. For their pharmaceutical exploitation, chemical methodologies that enable selective consecutive macrocyclizations are required. We disclose a combination...
9.
Schmidt M, Huang Y, Texeira de Oliveira E, Toplak A, Wijma H, Janssen D, et al.
Chembiochem
. 2019 Feb;
20(12):1524-1529.
PMID: 30735312
Disulfide-rich macrocyclic peptides-cyclotides, for example-represent a promising class of molecules with potential therapeutic use. Despite their potential their efficient synthesis at large scale still represents a major challenge. Here we...
10.
Steemers L, van Maarseveen J
Org Biomol Chem
. 2019 Feb;
17(8):2103-2106.
PMID: 30714599
C-Terminal dipeptide isopropenyl esters were synthesised by a Cu(ii)-mediated Chan-Lam-Evans enol esterification of peptide carboxylic acids and isoprenyl boroxine. These shelf stable peptide esters could be coupled stereoselectively with a...