Do Oxysterols Control Cholesterol Homeostasis?

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2002 Sep 18

PMID 12235099

Citations 75

Authors

Ingemar Bjorkhem

Affiliations

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References

Russell D . Nuclear orphan receptors control cholesterol catabolism. Cell. 1999; 97(5):539-42. DOI: 10.1016/s0092-8674(00)80763-1. View

Bjorkhem I, Andersson U, Ellis E, Alvelius G, Ellegard L, Diczfalusy U . From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. J Biol Chem. 2001; 276(40):37004-10. DOI: 10.1074/jbc.M103828200. View

DUANE W, JAVITT N . 27-hydroxycholesterol: production rates in normal human subjects. J Lipid Res. 1999; 40(7):1194-9. View

Bretillon L, Lutjohann D, Stahle L, Widhe T, Bindl L, Eggertsen G . Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res. 2000; 41(5):840-5. View

Lund E, Turley S, Russell D . Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem. 2000; 275(22):16536-42. DOI: 10.1074/jbc.M001811200. View

Bretillon L, Siden A, Wahlund L, Lutjohann D, Minthon L, Crisby M . Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. Neurosci Lett. 2000; 293(2):87-90. DOI: 10.1016/s0304-3940(00)01466-x. View

REPA J, Mangelsdorf D . The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol. 2000; 16:459-81. DOI: 10.1146/annurev.cellbio.16.1.459. View

Chiang J, Kimmel R, Stroup D . Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene. 2001; 262(1-2):257-65. DOI: 10.1016/s0378-1119(00)00518-7. View

Fu X, Menke J, Chen Y, Zhou G, MacNaul K, Wright S . 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001; 276(42):38378-87. DOI: 10.1074/jbc.M105805200. View

10.

Bodin K, Bretillon L, Aden Y, Bertilsson L, Broome U, Einarsson C . Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. J Biol Chem. 2001; 276(42):38685-9. DOI: 10.1074/jbc.M105127200. View

11.

Chawla A, REPA J, Evans R, Mangelsdorf D . Nuclear receptors and lipid physiology: opening the X-files. Science. 2001; 294(5548):1866-70. DOI: 10.1126/science.294.5548.1866. View

12.

Horton J, Goldstein J, Brown M . SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002; 109(9):1125-31. PMC: 150968. DOI: 10.1172/JCI15593. View

13.

Tall A, Costet P, Wang N . Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest. 2002; 110(7):899-904. PMC: 151157. DOI: 10.1172/JCI16391. View

14.

Tabas I . Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest. 2002; 110(7):905-11. PMC: 151158. DOI: 10.1172/JCI16452. View

15.

KANDUTSCH A, Chen H, Heiniger H . Biological activity of some oxygenated sterols. Science. 1978; 201(4355):498-501. DOI: 10.1126/science.663671. View

16.

KANDUTSCH A, Thompson E . Cytosolic proteins that bind oxygenated sterols. Cellular distribution, specificity, and some properties. J Biol Chem. 1980; 255(22):10813-21. View

17.

Tint G, Salen G . Biosynthesis of cholesterol, lanosterol, and delta 7-cholestenol, but not cholestanol, in cultured fibroblasts from normal individuals and patients with cerebrotendinous xanthomatosis. J Lipid Res. 1982; 23(4):597-603. View

18.

Erickson K, NES W . Inhibition of hepatic cholesterol synthesis in mice by sterols with shortened and stereochemically varied side chains. Proc Natl Acad Sci U S A. 1982; 79(16):4873-7. PMC: 346787. DOI: 10.1073/pnas.79.16.4873. View

19.

Pitas R, Boyles J, Lee S, Foss D, Mahley R . Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta. 1987; 917(1):148-61. DOI: 10.1016/0005-2760(87)90295-5. View

20.

Bjorkhem I, Reihner E, Angelin B, Ewerth S, Akerlund J, Einarsson K . On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans. J Lipid Res. 1987; 28(8):889-94. View