Solid-phase Synthesis of Combinatorial Libraries

Developments in the solid-phase synthesis of combinatorial libraries during 1998 are reviewed with emphasis on the rapid synthesis of libraries, new techniques for analysis of reaction progress and synthetic results, application of solid-phases as reagents, and synthesis of particular molecular entities. An alternative to solid-phase synthesis - fluorous-phase synthesis - is mentioned as an emerging technique that may compete with solid-phase synthesis in the future.