Apoptosis: Target of Cancer Therapy

Overview

Journal Clin Cancer Res

Specialty Oncology

Date 2002 Jul 13

PMID 12114400

Citations 75

Authors

Carlos G Ferreira

Mirjam Epping

Frank A E Kruyt

Giuseppe Giaccone

Affiliations

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Abstract

Recent knowledge on apoptosis has made it possible to devise novel approaches, which exploit this process to treat cancer. In this review, we discuss in detail approaches to induce tumor cell apoptosis, their mechanism of action, stage of development, and possible drawbacks. Finally, the obstacles yet to be overcome and the perspectives for potential clinical use of apoptosis-triggering approaches in cancer therapy in the future are assessed.

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