The Involvement of RNA in Ribosome Function

Overview

Journal Nature

Specialty Science

Date 2002 Jul 12

PMID 12110899

Citations 54

Authors

Peter B Moore

Thomas A Steitz

Affiliations

Soon will be listed here.

Abstract

The ribosome is a particle made of RNA and protein that is found in abundance in all cells that are actively making protein. It catalyses the messenger RNA-directed synthesis of proteins. Recent structural work has demonstrated a profound involvement of the ribosome's RNA component in all aspects of its function, supporting the hypothesis that proteins were added to the ribosome late in its evolution.

Citing Articles

Electron transport chain inhibition increases cellular dependence on purine transport and salvage.

Wu Z, Bezwada D, Cai F, Harris R, Ko B, Sondhi V Cell Metab. 2024; 36(7):1504-1520.e9.

PMID: 38876105 PMC: 11240302. DOI: 10.1016/j.cmet.2024.05.014.

A Proposal of the Ur-RNAome.

Palacios-Perez M, Jose M Genes (Basel). 2023; 14(12).

PMID: 38136981 PMC: 10743229. DOI: 10.3390/genes14122158.

Computational tools to study RNA-protein complexes.

Bheemireddy S, Sandhya S, Srinivasan N, Sowdhamini R Front Mol Biosci. 2022; 9:954926.

PMID: 36275618 PMC: 9585174. DOI: 10.3389/fmolb.2022.954926.

Modified Nucleotides for Chemical and Enzymatic Synthesis of Therapeutic RNA.

Graczyk A, Radzikowska-Cieciura E, Kaczmarek R, Pawlowska R, Chworos A Curr Med Chem. 2022; 30(11):1320-1347.

PMID: 36239720 DOI: 10.2174/0929867330666221014111403.

Determination of reference genes as a quantitative standard for gene expression analysis in mouse mesangial cells stimulated with TGF-β.

Dos Santos Bronel B, Anauate A, Maquigussa E, Boim M, da Silva Novaes A Sci Rep. 2022; 12(1):15626.

PMID: 36115882 PMC: 9482652. DOI: 10.1038/s41598-022-19548-z.