Tissue Attachment Strength of Prosthetic Meshes Used in Ventral and Incisional Hernia Repair. A Study in the New Zealand White Rabbit Adhesion Model

Overview

Journal Surg Endosc

Publisher Springer

Specialties Gastroenterology
General Surgery
Radiology

Date 2002 Jul 5

PMID 12098033

Citations 17

Authors

K A LeBlanc

D Bellanger

K V Rhynes 5th

D G Baker

R W Stout

Affiliations

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Abstract

Background: Many prosthetic materials are used in incisional hernia repair, including polypropylene (PP) and expanded polytetrafluoroethylene (ePTFE). However, PP forms severe adhesions and ePTFE has raised concerns about the adequacy of tissue attachment.

Methods: The early tissue attachment strength of PP and two new forms of ePTFE (DLM and DLMC) was compared in a rabbit model (n = 12) in which disks of the three meshes (n = 8 of each material) were implanted against the abdominal wall for 3 days.

Results: Tensiometer testing found that DLMC mesh had significantly greater attachment strength than PP (p = 0.02). Histologic studies indicated that this was due to cellular ingrowth. Tissue adhesions were observed with all eight PP disks, one DLMC disk, and none of the DLM disks.

Conclusion: Modified forms of ePTFE mesh may provide abdominal wall repairs that are as strong or stronger than those obtained with PP, with early tissue attachment and without adhesions.

Citing Articles

Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair.

Luan F, Cao W, Cao C, Li B, Shi X, Gao C Front Bioeng Biotechnol. 2022; 10:949917.

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Techniques for Closing the Abdominal Wall in Intestinal and Multivisceral Transplantation: A Systematic Review.

Fortunato A, Pinheiro R, Matsumoto C, Arantes R, Rocha-Santos V, Nacif L Ann Transplant. 2022; 27:e934595.

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Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis.

Liu H, van Steensel S, Gielen M, Vercoulen T, Melenhorst J, Winkens B Hernia. 2019; 24(6):1253-1261.

PMID: 31659548 PMC: 7701080. DOI: 10.1007/s10029-019-02071-y.

Evaluation of human acellular dermis versus porcine acellular dermis in an in vivo model for incisional hernia repair.

Ngo M, Aberman H, Hawes M, Choi B, Gertzman A Cell Tissue Bank. 2011; 12(2):135-45.

PMID: 21380733 PMC: 3082045. DOI: 10.1007/s10561-011-9245-5.

Use of negative pressure wound therapy in the management of infected abdominal wounds containing mesh: an analysis of outcomes.

Baharestani M, Gabriel A Int Wound J. 2010; 8(2):118-25.

PMID: 21176107 PMC: 7950637. DOI: 10.1111/j.1742-481X.2010.00756.x.