The New Stem Cell Biology

Overview

Journal Trans Am Clin Climatol Assoc

Specialty Rehabilitation Medicine

Date 2002 Jun 11

PMID 12053709

Citations 6

Authors

Peter J Quesenberry

Gerald A Colvin

Jean-Francois Lambert

Angela E Frimberger

Mark S Dooner

Christina I McAuliffe

Caroline Miller

Pamela Becker

Evangelis Badiavas

Vincent J Falanga

Gerald Elfenbein

Lawrence G Lum

Affiliations

Soon will be listed here.

Abstract

Recent studies have indicated that bone marrow stem cells are capable of generating muscle, cardiac, hepatic, renal, and bone cells. Purified hematopoietic stem cells have generated cardiac and hepatic cells and reversed disease manifestations in these tissues. Hematopoietic stem cells also alter phenotype with cell cycle transit or circadian phase. During a cytokine stimulated cell cycle transit, reversible alterations of differentiation and engraftment occur. Primitive hematopoietic stem cells express a wide variety of adhesion and cytokine receptors and respond quickly with migration and podia extensions on exposure to cytokines. These data suggest an "Open Chromatin" model of stem cell regulation in which there is a fluctuating continuum in the stem cell/progenitor cell compartments, rather than a hierarchical relationship. These observations, along with progress in using low dose treatments and tolerization approaches, suggest many new therapeutic strategies involving stem cells and the creation of a new medical specialty; stemology.

Citing Articles

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Stem cell plasticity revisited: the continuum marrow model and phenotypic changes mediated by microvesicles.

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Human artificial chromosome vectors meet stem cells: new prospects for gene delivery.

Ren X, Tahimic C, Katoh M, Kurimasa A, Inoue T, Oshimura M Stem Cell Rev. 2006; 2(1):43-50.

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Bone marrow cells and myocardial regeneration.

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