Developmentally Regulated Expression of the Nerve Growth Factor Receptor Gene in the Periphery and Brain

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1987 May 1

PMID 3033677

Citations 17

Authors

C R Buck

H J Martinez

I B Black

M V Chao

Affiliations

Soon will be listed here.

Abstract

Nerve growth factor (NGF) regulates development and maintenance of function of peripheral sympathetic and sensory neurons. A potential role for the trophic factor in brain has been detected only recently. The ability of a cell to respond to NGF is due, in part, to expression of specific receptors on the cell surface. To study tissue-specific expression of the NGF receptor gene, we have used sensitive cRNA probes for detection of NGF receptor mRNA. Our studies indicate that the receptor gene is selectively and specifically expressed in sympathetic (superior cervical) and sensory (dorsal root) ganglia in the periphery, and by the septum-basal forebrain centrally, in the neonatal rat in vivo. Moreover, examination of tissues from neonatal and adult rats reveals a marked reduction in steady-state NGF receptor mRNA levels in sensory ganglia. In contrast, a 2- to 4-fold increase was observed in the basal forebrain and in the sympathetic ganglia over the same time period. Our observations suggest that NGF receptor mRNA expression is developmentally regulated in specific areas of the nervous system in a differential fashion.

Citing Articles

Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering.

Mobini S, Song Y, McCrary M, Schmidt C Biomaterials. 2018; 198:146-166.

PMID: 29880219 PMC: 6957334. DOI: 10.1016/j.biomaterials.2018.05.012.

Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon.

Bains M, Cousins J, Roberts J Exp Neurol. 2007; 204(2):767-76.

PMID: 17320868 PMC: 3841287. DOI: 10.1016/j.expneurol.2007.01.020.

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.

Yamashita T, Higuchi H, Tohyama M J Cell Biol. 2002; 157(4):565-70.

PMID: 12011108 PMC: 2173856. DOI: 10.1083/jcb.200202010.

Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy.

Syroid D, Maycox P, Soilu-Hanninen M, Petratos S, Bucci T, Burrola P J Neurosci. 2000; 20(15):5741-7.

PMID: 10908614 PMC: 6772552.

Glucocorticoids and the hippocampus. Developmental interactions facilitating the expression of behavioral inhibition.

Takahashi L Mol Neurobiol. 1996; 13(3):213-26.

PMID: 8989771 DOI: 10.1007/BF02740624.

References

Frazier W, Boyd L, Szutowicz A, Pulliam M, Bradshaw R . Specific binding sites for 125I-nerve growth factor in peripheral tissues and brain. Biochem Biophys Res Commun. 1974; 57(4):1096-103. DOI: 10.1016/0006-291x(74)90809-2. View

Herrup K, SHOOTER E . Properties of the beta-nerve growth factor receptor in development. J Cell Biol. 1975; 67(1):118-25. PMC: 2109576. DOI: 10.1083/jcb.67.1.118. View

Sutter A, Riopelle R, Harris-Warrick R, SHOOTER E . Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem. 1979; 254(13):5972-82. View

Black I . Regulation of autonomic development. Annu Rev Neurosci. 1978; 1:183-214. DOI: 10.1146/annurev.ne.01.030178.001151. View

Chirgwin J, Przybyla A, MacDonald R, Rutter W . Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979; 18(24):5294-9. DOI: 10.1021/bi00591a005. View

Landreth G, SHOOTER E . Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states. Proc Natl Acad Sci U S A. 1980; 77(8):4751-5. PMC: 349924. DOI: 10.1073/pnas.77.8.4751. View

Thoenen H, Barde Y . Physiology of nerve growth factor. Physiol Rev. 1980; 60(4):1284-335. DOI: 10.1152/physrev.1980.60.4.1284. View

Schechter A, Bothwell M . Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association. Cell. 1981; 24(3):867-74. DOI: 10.1016/0092-8674(81)90112-4. View

Massague J, Guillette B, Czech M, Morgan C, Bradshaw R . Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling. J Biol Chem. 1981; 256(18):9419-24. View

10.

Honegger P, Lenoir D . Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures. Brain Res. 1982; 255(2):229-38. DOI: 10.1016/0165-3806(82)90023-2. View

11.

Rohrer H, Barde Y . Presence and disappearance of nerve growth factor receptors on sensory neurons in culture. Dev Biol. 1982; 89(2):309-15. DOI: 10.1016/0012-1606(82)90320-7. View

12.

Naujoks K, Korsching S, Rohrer H, Thoenen H . Nerve growth factor-mediated induction of tyrosine hydroxylase and of neurite outgrowth in cultures of bovine adrenal chromaffin cells: dependence on developmental stage. Dev Biol. 1982; 92(2):365-79. DOI: 10.1016/0012-1606(82)90182-8. View

13.

Puma P, Buxser S, Watson L, Kelleher D, Johnson G . Purification of the receptor for nerve growth factor from A875 melanoma cells by affinity chromatography. J Biol Chem. 1983; 258(5):3370-5. View

14.

Gnahn H, Hefti F, Heumann R, Schwab M, Thoenen H . NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?. Brain Res. 1983; 285(1):45-52. DOI: 10.1016/0165-3806(83)90107-4. View

15.

Cox K, DeLeon D, Angerer L, Angerer R . Detection of mrnas in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev Biol. 1984; 101(2):485-502. DOI: 10.1016/0012-1606(84)90162-3. View

16.

Hefti F, Dravid A, Hartikka J . Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain Res. 1984; 293(2):305-11. DOI: 10.1016/0006-8993(84)91237-x. View

17.

Seiler M, Schwab M . Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain Res. 1984; 300(1):33-9. DOI: 10.1016/0006-8993(84)91338-6. View

18.

Melton D, Krieg P, Rebagliati M, Maniatis T, Zinn K, Green M . Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 1984; 12(18):7035-56. PMC: 320141. DOI: 10.1093/nar/12.18.7035. View

19.

Ross A, Grob P, Bothwell M, Elder D, Ernst C, Marano N . Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proc Natl Acad Sci U S A. 1984; 81(21):6681-5. PMC: 391994. DOI: 10.1073/pnas.81.21.6681. View

20.

Hosang M, SHOOTER E . Molecular characteristics of nerve growth factor receptors on PC12 cells. J Biol Chem. 1985; 260(1):655-62. View