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Integrating MRNA Processing with Transcription

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2002 Mar 23
PMID 11909521
Citations 456
Authors
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Abstract

The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.

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