Unraveling Docking and Initiation of MRNA Export Through the Nuclear Pore Complex

Overview

Journal Bioessays

Publisher Wiley

Specialties Biology
Cell Biology
Molecular Biology

Date 2022 Jun 27

PMID 35754154

Authors

Mark Tingey

Weidong Yang

Affiliations

Soon will be listed here.

Abstract

The nuclear export of mRNA through the nuclear pore complex (NPC) is a process required for the healthy functioning of human cells, making it a critical area of research. However, the geometries of mRNA and the NPC are well below the diffraction limit of light microscopy, thereby presenting significant challenges in evaluating the discrete interactions and dynamics involved in mRNA nuclear export through the native NPC. Recent advances in biotechnology and single-molecule super-resolution light microscopy have enabled researchers to gain granular insight into the specific contributions made by discrete nucleoporins in the nuclear basket of the NPC to the export of mRNA. Specifically, by expanding upon the docking step facilitated by the protein TPR in the nuclear basket as well as identifying NUP153 as being the primary nuclear basket protein initiating export through the central channel of the NPC.

Citing Articles

Deciphering vesicle-assisted transport mechanisms in cytoplasm to cilium trafficking.

Tingey M, Ruba A, Jiang Z, Yang W Front Cell Neurosci. 2024; 18:1379976.

PMID: 38860265 PMC: 11163138. DOI: 10.3389/fncel.2024.1379976.

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