Synthesis and Vasorelaxant Activity of New Coumarin and Furocoumarin Derivatives

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2002 Feb 23

PMID 11859002

Citations 6

Authors

Manuel Campos-Toimil

Francisco Orallo

Lourdes Santana

Eugenio Uriarte

Affiliations

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Abstract

We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new and more efficient vasodilator drugs.

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