Tyrosinase Inhibitor Activity of Coumarin-resveratrol Hybrids

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2009 Jul 28

PMID 19633620

Citations 17

Authors

Antonella Fais

Marcella Corda

Benedetta Era

M Benedetta Fadda

Maria Joao Matos

Elias Quezada

Lourdes Santana

Carmen Picciau

Gianni Podda

Giovanna Delogu

Affiliations

Soon will be listed here.

Abstract

In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC(50) values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.

Citing Articles

Synergistic Biomedical Potential and Molecular Docking Analyses of Coumarin-Triazole Hybrids as Tyrosinase Inhibitors: Design, Synthesis, In Vitro Profiling, and In Silico Studies.

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