Irresistible IRES. Attracting the Translation Machinery to Internal Ribosome Entry Sites

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2001 Oct 16

PMID 11600453

Citations 100

Authors

S Vagner

B Galy

S Pyronnet

Affiliations

Soon will be listed here.

Abstract

Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

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